UniProt Accession

 CSGD_ECOLI; P52106 

Genbank Protein ID

 X90754; U00096; AP009048; AF081826 

Genbank Nucleotide ID

 CAA62280.1; AAC74124.1; BAA35830.1; AAD16025.1 

Protein Name

 CsgBAC operon transcriptional regulatory protein 

Protein Synonyms/Alias

  

Gene Name

 csgD 

Gene Synonyms/Alias

 b1040; JW1023 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
166	REKEILNKLRIGASN	acetylation	[1]
188	FISENTVKTHLYNLF	acetylation	[1]
196	THLYNLFKKIAVKNR	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 The master regulator for adhesive curli fimbriae expression; necessary for transcription of the csgBAC/ymdA operon. Plays a positive role in biofilm formation. May have the capability to respond to starvation and/or high cell density by activating csgBA transcription. Low-level constitutive expression confers an adherent curli fimbriae-expressing phenotype, up- regulates 10 genes and down-regulates 14 others. 

Sequence Annotation

 DOMAIN 149 214 HTH luxR-type.
 DNA_BIND 173 192 H-T-H motif (By similarity).  

Keyword

 Cell inner membrane; Cell membrane; Complete proteome; DNA-binding; Membrane; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 216 AA 

Protein Sequence

Gene Ontology

 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0000986; F:bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding; IDA:EcoCyc.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:2000144; P:positive regulation of DNA-dependent transcription, initiation; IMP:EcoCyc.
 GO:1900190; P:regulation of single-species biofilm formation; IDA:EcoCyc.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR016032; Sig_transdc_resp-reg_C-effctor.
 IPR000792; Tscrpt_reg_LuxR_C.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00196; GerE 

SMART

 SM00421; HTH_LUXR 

PROSITE

 PS00622; HTH_LUXR_1
 PS50043; HTH_LUXR_2 

PRINTS

 PR00038; HTHLUXR.