CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034718
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein Actn2 
Protein Synonyms/Alias
 RCG30552 
Gene Name
 Actn2 
Gene Synonyms/Alias
 rCG_30552 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
38LLDPAWEKQQRKTFTacetylation[1]
96RGKMRFHKIANVNKAacetylation[1]
221LAMEIAEKHLDIPKMacetylation[1]
239EDIVNTPKPDERAIMacetylation[1]
311LENRTPEKTMQAMQKacetylation[1]
318KTMQAMQKKLEDFRDacetylation[1]
319TMQAMQKKLEDFRDYacetylation[1]
338KPPKVQEKCQLEINFacetylation[1]
366AFMPSEGKMVSDIAGacetylation[1]
383QRLEQAEKGYEEWLLacetylation[1]
405RLEHLAEKFRQKASTacetylation[1]
613ELRNKWDKVKQLVPVacetylation[1]
615RNKWDKVKQLVPVRDacetylation[1]
679EDQMNQLKQYEHNIIacetylation[1]
748QILTRDAKGITQEQMacetylation[1]
842FRILASDKPYILAEEacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Actin-binding; Calcium; Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 894 AA 
Protein Sequence
MNQIEPGVQY NYVYDEDEYM IQEEEWDRDL LLDPAWEKQQ RKTFTAWCNS HLRKAGTQIE 60
NIEEDFRNGL KLMLLLEVIS GERLPKPDRG KMRFHKIANV NKALDYIASK GVKLVSIGAE 120
EIVDGNVKMT LGMIWTIILR FAIQDISVEE TSAKEGLLLW CQRKTAPYRN VNIQNFHTSW 180
KDGLGLCALI HRHRPDLIDY SKLNKDDPIG NINLAMEIAE KHLDIPKMLD AEDIVNTPKP 240
DERAIMTYVS CFYHAFAGAE QAETAANRIC KVLAVNQENE RLMEEYERLA SELLEWIRRT 300
IPWLENRTPE KTMQAMQKKL EDFRDYRRKH KPPKVQEKCQ LEINFNTLQT KLRISNRPAF 360
MPSEGKMVSD IAGAWQRLEQ AEKGYEEWLL NEIRRLERLE HLAEKFRQKA STHETWAYGK 420
EQILLQKDYE SASLTEVRAL LRKHEAFESD LAAHQDRVEQ IAAIAQELNE LDYHDAVNVN 480
DRCQKICDQW DRLGTLTQKR REALERTEKL LETIDQLHLE FAKRAAPFNN WMEGAMEDLQ 540
DMFIVHSIEE IQSLITAHEQ FKATLPEADG ERQSILAIQN EVEKVIQSYS IRISSSNPYS 600
TVTMDELRNK WDKVKQLVPV RDQSLQEELA RQHANERLRR QFAAQANAIG PWIQNKMEEI 660
ARSSIQITGA LEDQMNQLKQ YEHNIINYKN NIDKLEGDHQ LIQEALVFDN KHTNYTMEHI 720
RVGWELLLTT IARTINEVET QILTRDAKGI TQEQMNEFRA SFNHFDRRKN GLMDHEDFRA 780
CLISMGYDLG EAEFARIMTL VDPNGQGTVT FQSFIDFMTR ETADTDTAEQ VIASFRILAS 840
DKPYILAEEL RRELPPDQAQ YCIKRMPPYS GPGSVPGALD YTAFSSALYG ESDL 894 
Gene Ontology
 GO:0030175; C:filopodium; IEA:Compara.
 GO:0005925; C:focal adhesion; IEA:Compara.
 GO:0030018; C:Z disc; IEA:Compara.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0030375; F:thyroid hormone receptor coactivator activity; IEA:Compara.
 GO:0051764; P:actin crosslink formation; IEA:InterPro.
 GO:0051017; P:actin filament bundle assembly; IEA:InterPro.
 GO:0048041; P:focal adhesion assembly; IEA:Compara.
 GO:0030035; P:microspike assembly; IEA:Compara.
 GO:0006936; P:muscle contraction; IEA:Compara.
 GO:1901017; P:negative regulation of potassium ion transmembrane transporter activity; IEA:Compara.
 GO:0043267; P:negative regulation of potassium ion transport; IEA:Compara.
 GO:2000009; P:negative regulation of protein localization to cell surface; IEA:Compara.
 GO:1901018; P:positive regulation of potassium ion transmembrane transporter activity; IEA:Compara.
 GO:0043268; P:positive regulation of potassium ion transport; IEA:Compara.
 GO:0051289; P:protein homotetramerization; IEA:Compara.
 GO:0042391; P:regulation of membrane potential; IEA:Compara. 
Interpro
 IPR001589; Actinin_actin-bd_CS.
 IPR026921; Alpha-actinin.
 IPR001715; CH-domain.
 IPR011992; EF-hand-like_dom.
 IPR014837; EF-hand_Ca_insen.
 IPR002048; EF_hand_dom.
 IPR018159; Spectrin/alpha-actinin.
 IPR002017; Spectrin_repeat. 
Pfam
 PF00307; CH
 PF08726; efhand_Ca_insen
 PF00435; Spectrin 
SMART
 SM00033; CH
 SM00054; EFh
 SM00150; SPEC 
PROSITE
 PS00019; ACTININ_1
 PS00020; ACTININ_2
 PS50021; CH
 PS50222; EF_HAND_2 
PRINTS