| Tag | Content |
|---|
| CPLM ID | CPLM-022586 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein IMPACT |
Protein Synonyms/Alias | Imprinted and ancient gene protein homolog |
Gene Name | IMPACT |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 127 | TEPGPDVKKKTEEED | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Translational regulator that ensures constant high levels of translation under amino acid starvation. Acts by interacting with GCN1/GCN1L1, thereby preventing activation of GCN2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis (By similarity). |
Sequence Annotation | DOMAIN 14 116 RWD. |
Keyword | Alternative splicing; Complete proteome; Polymorphism; Reference proteome; Translation regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 320 AA |
Protein Sequence | MAEGDAGSDQ RQNEEIEAMA AIYGEEWCVI DDCAKIFCIR ISDDIDDPKW TLCLQVMLPN 60
EYPGTAPPIY QLNAPWLKGQ ERADLSNSLE EIYIQNIGES ILYLWVEKIR DVLIQKSQMT 120
EPGPDVKKKT EEEDVECEDD LILACQPESS LKALDFDISE TRTEVEVEEL PPIDHGIPIT 180
DRRSTFQAHL APVVCPKQVK MVLSKLYENK KIASATHNIY AYRIYCEDKQ TFLQDCEDDG 240
ETAAGGRLLH LMEILNVKNV MVVVSRWYGG ILLGPDRFKH INNCARNILV EKNYTNSPEE 300
SSKALGKNKK VRKDKKRNEH 320 |
Gene Ontology | GO:0001933; P:negative regulation of protein phosphorylation; IEA:Compara. GO:0006446; P:regulation of translational initiation; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |