Tag | Content |
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CPLM ID | CPLM-015172 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Integrator complex subunit 1 |
Protein Synonyms/Alias | Int1 |
Gene Name | Ints1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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1873 | DANMACRKLAVAHPV | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (By similarity). |
Sequence Annotation | MOD_RES 47 47 N6-acetyllysine (By similarity). MOD_RES 307 307 Phosphoserine (By similarity). MOD_RES 1320 1320 Phosphoserine (By similarity). MOD_RES 1328 1328 Phosphoserine. MOD_RES 1329 1329 Phosphoserine. |
Keyword | Acetylation; Complete proteome; Membrane; Nucleus; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 2195 AA |
Protein Sequence | MNRAKPTTVR RPSAAAKPSG HPPPGDFIAL GSKGQASESK TTSTLLKPAP SGLPSERKRD 60 ASASLSGTSA LTGLTKRPKL SSTPPLSALG RLAEAAVAEK RAISPSIKEP SVVPIEVLPT 120 VLLDEIEAAE LEGNDDRIEG VLCGAVKQLK VTRAKPDSTL YLSLMYLAKI KPNIFATEGV 180 IEALCSLLRR DASVNFKAKG NSLVSVLACN LLMAAYEEDE NWPEIFVKVY IEDSLGERIW 240 VDSPHCRTFV DNIQTAFNTK MPPKSVLLQG EGARSGGELG AGSSPHPSLT EEEDSQTELL 300 IAEEKLSPEQ EGQLMPRPRY DELTESVEEY VLDMLRDQLN RRQPIDNVSR NLLRLLTATC 360 GYKEVRLLAV QRLEMWLQNP KLTRPAQDLL MSVCMNCNSH GSEDMDVISH LIKIRLKPKV 420 LLNHYMLCIR ELLNAHKDNL GTTIKFVIFN ELSNARNPNN MQILYTVLQH SSELAPKFLA 480 MVFQDLLTNK DDYLRASRAL LREIIKQTKH EINFQAFCLG LMQERKEPQY LEMEFKERFV 540 VHITDVLAVS MMLGITAQVK EAGVAWDKGE KRNLEVLRTF QNQIAAIQRD AVWWLHTVVP 600 SVSKLAPKDY VHCLHKVLFT EQPETYYKWD NWPPESDRNF FLRLCSEVPI LEDTLMRVLV 660 IGLSRELPLG PADAMELADH LVKRAAAVQA DDVEVLKVER IQLIDAVLNL CTYHHPENIQ 720 LPPGYQPPNL AISTLYWKAW PLLLVVAAFN PENIGLAAWE EYPTLKMLME MVMTNNYSYP 780 PCTLTDEETR TEMINRELQI SQREKQEILA FEGHLAAAST KQTITESSSL LLSQLTSLDP 840 QGPPRRPPPH ILDQVKALNQ SLRLGHLLCR SRNPDFLLHI IQRQASSQSM PWLADLVQSS 900 EGSLDVLPVQ CLCEFLLHDA ADSTASGEED DEGESREQKA KKRQRQQKQR QLLGRLQDLL 960 LGPKADEQTT CEVLDYFLRR LGSSQVASRV LAMKGLSLVL SEGGLRDKEE KEPPMEEDIG 1020 ETDALQGYQW LLRDLPRLPL FDSVRTTTAL ALQQAIHMET DPQTISAYLI YLSQHTPVEE 1080 QGPHSDLALD VARLVVERST IMAHLFSKPS CSTASDAVLS ALLSVFSRYV RRMRKSKEGE 1140 EVYSWSESQD QVFLRWSSGE TATMHILVVH AMVILLTLGP PRSGDSEFSE LLDIWFPEKK 1200 PLPTAFLVDT SEEALLLPDW LKLRMIRSEV PRLVDAALQD LEPQQLLLFV QSFGIPVSSM 1260 SKLLQYLDQA VAQDPQTLEQ NIMDKNYMAH LVEVQHERGA SGGQTFHSLL TASLPPRRDS 1320 TEAPKPESSP EPPPGQGRTR AGTQVPVLGP EDDLAGIFLQ IFPLSPDPRW QSSSPRPLAL 1380 ALQQALGQEL ARVRQGNPEV PGITVRLLQA MTTLLSSPHG GTLALAMHHS HFLSCPLMRQ 1440 LYQYQRAVPQ DTGFSSLFLK VLMQILQWLD SPAVEDGPLQ AQLKLFATRY SARHRISDVR 1500 SGLLHLADAL SFHGDLEVAN STARAVIATL RSGEKCPVEP ELISKVLRGL IEVRSPHLEE 1560 LLTALFSATT ETSCPSPASG PIVVVSSLLL QEKEELLGPS KQEVEGASTE AMRLGPASGL 1620 LVDWLETLDP EVVCSCPDLQ WKLLFSRRKG KGHISAQVLS FRPYLLALLT HQASWSTLHC 1680 CIRVLLGKSR EQRLDPSASL DFLWACIHVP RIWQGRDQRT PQKRREELVL HVQGPELLSL 1740 VELILSEAET RSQDGDSAAR TLIQTRLPLL LSCCRSNDES IGKVTEHLTS CIQQWGDSVL 1800 GQRCRDLLLQ LYLQRPEVRV PVPEVLLQSE GATSSSICKL DGLVHRFITL LADTSDSRSS 1860 ESRVADANMA CRKLAVAHPV LLLRHLPMIA ALLHGRTHLN FQEFRQQNHL AFFLHVLGIL 1920 ELLQPRVFQS EHQGALWDCL RSFIRLLLNY RKSSRHLAPF ISKFVQFIHK YVGCSAPAAV 1980 AFLQKHAEPL HDLSFDNSDL VMLKSLLAGL SLPSRDGRTD QGLDEEGEDE RSAGSLPLVS 2040 VSLSTPLTVA DVAPHMKRLS RGRAVEDVLE TLSDIDEMSR RRPEVLGFFS TNLQRLMSSA 2100 EESCRNLAFS LALRSIQNNP SIAADFLPTF MYCLGSRDFE VVQTALRNLP EYTLLCQEHA 2160 AVLLHRAFLV GVYGQIDTSA QISEALKILH MEAVM 2195 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0032039; C:integrator complex; IEA:Compara. GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IDA:MGI. GO:0001833; P:inner cell mass cell proliferation; IMP:MGI. GO:0043066; P:negative regulation of apoptotic process; IMP:MGI. GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:MGI. GO:0034474; P:U2 snRNA 3'-end processing; IMP:MGI. |
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