CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031481
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Short transient receptor potential channel 4-associated protein 
Protein Synonyms/Alias
 cDNA FLJ50335, highly similar to Trpc4-associated protein 
Gene Name
 TRPC4AP 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
70TERDKQSKWSGIPQLubiquitination[1, 2]
118SIRGQKLKISDEMSKubiquitination[3]
143VCTEGVTKRLAEKNDubiquitination[2]
179IEDILGVKKEMIRLDubiquitination[2, 3, 4]
224MDTGNDDKHTLLAKNubiquitination[2]
230DKHTLLAKNAQQKKSubiquitination[2, 3]
236AKNAQQKKSLSLGPSubiquitination[1, 2, 3, 5]
264GFVERLCKLATRKVSubiquitination[2, 3, 5]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 758 AA 
Protein Sequence
MAAAPVAAGS GAGRGRRSAA TVAAWGGWGG RPRPGNILLQ LRQGQLTGRG LVRAVQFTET 60
FLTERDKQSK WSGIPQLLLK LHTTSHLHSD FVECQNILKL LVEILMRPTI SIRGQKLKIS 120
DEMSKDCLSI LYNTCVCTEG VTKRLAEKND FVIFLFTLMT SKKTFLQTAT LIEDILGVKK 180
EMIRLDEVPN LSSLVSNFDQ QQLANFCRIL AVTISEMDTG NDDKHTLLAK NAQQKKSLSL 240
GPSAAEINQA ALLSIPGFVE RLCKLATRKV SESTGTASFL QELEEWYTWL DNALVLDALM 300
RVANEESEHN QASIVFPPPG ASEENGLPHT SARTQLPQSM KIMHEIMYKL EVLYVLCVLL 360
MGRQRNQVHR MIAEFKLIPG LNNLFDKLIW RKHSASALVL HGHNQNCDCS PDITLKIQFL 420
RLLQSFSDHH ENKYLLLNNQ ELNELSAISL KANIPEVEAV LNTDRSLVCD GKRGLLTRLL 480
QVMKKEPAES SFRFWQARAV ESFLRGTTSY ADQMFLLKRG LLEHILYCIV DSECKSRDVL 540
QSYFDLLGEL MKFNVDAFKR FNKYINTDAK FQVFLKQINS SLVDSNMLVR CVTLSLDRFE 600
NQVDMKVAEV LSECRLLAYI SQVPTQMSFL FRLINIIHVQ TLTQENVSCL NTSLVILMLA 660
RRKERLPLYL RLLQRMEHSK KYPGFLLNNF HNLLRFWQQH YLHKDKDSTC LENSSCISFS 720
YWKETVSILL NPDRQSPSAL VSYIEEPYMD IDRDFTEE 758 
Gene Ontology
  
Interpro
 IPR022162; DUF3689. 
Pfam
 PF12463; DUF3689 
SMART
  
PROSITE
  
PRINTS