UniProt Accession

 KAT3_HUMAN; Q6YP21; B3KQ13; O95335; Q5JS27; Q5T9T7; Q5T9T8; Q6AI27; Q6ICW1; Q9BVY5 

Genbank Protein ID

 AY028624; CR627392; AK057176; AL445991; AL139416; AL445991; AL445991; AL139416; AL139416; AL445991; AL445991; AL139416; BC000819; AF091090; CR450282 

Genbank Nucleotide ID

 AAK26163.1; CAH10487.1; BAG51875.1; CAI41345.1; CAI21695.1; CAI21695.1; CAI41339.1; CAI41339.1; CAI21696.1; CAI21696.1; CAI41340.1; CAI41340.1; AAH00819.1; AAC72959.1; CAG29278.1 

Protein Name

 Kynurenine--oxoglutarate transaminase 3 

Protein Synonyms/Alias

 Cysteine-S-conjugate beta-lyase 2; Kynurenine aminotransferase III; KATIII; Kynurenine--glyoxylate transaminase; Kynurenine--oxoglutarate transaminase III 

Gene Name

 CCBL2 

Gene Synonyms/Alias

 KAT3 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
82	ISPPTYVKEELSKIA	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). May catalyze the beta-elimination of S-conjugates and Se- conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (By similarity). Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2- oxoglutarate as amino group acceptor (in vitro) (By similarity). 

Sequence Annotation

 BINDING 53 53 Substrate (By similarity).
 BINDING 71 71 Substrate; via amide nitrogen (By
 BINDING 218 218 Substrate (By similarity).
 BINDING 429 429 Substrate (By similarity).
 MOD_RES 116 116 N6-acetyllysine.
 MOD_RES 280 280 N6-(pyridoxal phosphate)lysine (By  

Keyword

 Acetylation; Alternative splicing; Aminotransferase; Complete proteome; Lyase; Polymorphism; Pyridoxal phosphate; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 454 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0047804; F:cysteine-S-conjugate beta-lyase activity; IEA:EC.
 GO:0047315; F:kynurenine-glyoxylate transaminase activity; ISS:UniProtKB.
 GO:0016212; F:kynurenine-oxoglutarate transaminase activity; ISS:UniProtKB.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0006103; P:2-oxoglutarate metabolic process; IEA:Compara.
 GO:0009058; P:biosynthetic process; IEA:InterPro.
 GO:0006569; P:tryptophan catabolic process; TAS:Reactome. 

Interpro

 IPR004839; Aminotransferase_I/II.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2. 

Pfam

 PF00155; Aminotran_1_2 

SMART

  

PROSITE

  

PRINTS