CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038186
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 NAD-dependent protein deacetylase sirtuin-2 
Protein Synonyms/Alias
  
Gene Name
 Sirt2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
56FEISYFKKHPEPFFAubiquitination[1]
74ELYPGQFKPTICHYFubiquitination[1]
132CVNTSCRKEYTMGWMubiquitination[1]
140EYTMGWMKEKIFSEAubiquitination[1]
217TPRLLINKEKTGQTDubiquitination[1]
269ADLLGWKKELEDLVRubiquitination[1]
301STTISPGKSPPPAKEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 319 AA 
Protein Sequence
MAEPDRRKVI CLVGAGISTS AGIPDFRSPS TGLYANLEKY HLPYPEAIFE ISYFKKHPEP 60
FFALAKELYP GQFKPTICHY FIRLLKEKGL LLRCYTQNID TLERVAGLEP QDLVEAHGTF 120
YTSHCVNTSC RKEYTMGWMK EKIFSEATPR CEQCQSVVKP DIVFFGENLP SRFFSCMQSD 180
FSKVDLLIIM GTSLQVQPFA SLISKAPLAT PRLLINKEKT GQTDPFLGMM MGLGGGMDFD 240
SKKAYRDVAW LGDCDQGCLA LADLLGWKKE LEDLVRREHA NIDAQSGSQA PNPSTTISPG 300
KSPPPAKEAA RTKEKEEQQ 319 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0016811; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; IEA:InterPro.
 GO:0070403; F:NAD+ binding; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0016575; P:histone deacetylation; IGI:MGI.
 GO:0090042; P:tubulin deacetylation; IGI:MGI. 
Interpro
 IPR017328; NAD-dep_deAcase_SIR2_class_I.
 IPR003000; Sirtuin.
 IPR026590; Ssirtuin_cat_dom. 
Pfam
 PF02146; SIR2 
SMART
  
PROSITE
 PS50305; SIRTUIN 
PRINTS