CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007457
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein C-ets-1 
Protein Synonyms/Alias
 p54 
Gene Name
 Ets1 
Gene Synonyms/Alias
 Ets-1 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
2******MKAAVDLKPacetylation[1]
8MKAAVDLKPTLTIIKacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405
Functional Description
 Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion (By similarity). 
Sequence Annotation
 DOMAIN 51 136 PNT.
 DNA_BIND 335 415 ETS.
 REGION 130 243 Activation domain; required for
 MOD_RES 8 8 N6-acetyllysine (By similarity).
 MOD_RES 15 15 N6-acetyllysine; alternate (By
 MOD_RES 38 38 Phosphothreonine; by MAPK (By
 MOD_RES 223 223 Phosphotyrosine (By similarity).
 MOD_RES 270 270 Phosphoserine (By similarity).
 MOD_RES 285 285 Phosphoserine (By similarity).
 MOD_RES 305 305 N6-acetyllysine (By similarity).
 CROSSLNK 15 15 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 227 227 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 Acetylation; Alternative splicing; Complete proteome; DNA-binding; Immunity; Isopeptide bond; Nucleus; Phosphoprotein; Proto-oncogene; Reference proteome; Transcription; Transcription regulation; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 441 AA 
Protein Sequence
MKAAVDLKPT LTIIKTEKVD LELFPSPDME CADVPLLTPS SKEMMSQALK ATFSGFTKEQ 60
QRLGIPKDPR QWTETHVRDW VMWAVNEFSL KGVDFQKFCM NGAALCALGK ECFLELAPDF 120
VGDILWEHLE ILQKEDVKPY QVNGVNPTYP ESRYTSDYFI SYGIEHAQCV PPSEFSEPSF 180
ITESYQTLHP ISSEELLSLK YENDYPSVIL RDPLQTDTLQ TDYFAIKQEV LTPDNMCMGR 240
ASRGKLGGQD SFESIESYDS CDRLTQSWSS QSSFNSLQRV PSYDSFDSED YPAALPNHKP 300
KGTFKDYVRD RADLNKDKPV IPAAALAGYT GSGPIQLWQF LLELLTDKSC QSFISWTGDG 360
WEFKLSDPDE VARRWGKRKN KPKMNYEKLS RGLRYYYDKN IIHKTAGKRY VYRFVCDLQS 420
LLGYTPEELH AMLDVKPDAD E 441 
Gene Ontology
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0005667; C:transcription factor complex; IEA:Compara.
 GO:0043565; F:sequence-specific DNA binding; IDA:RGD.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; ISS:UniProtKB.
 GO:0060055; P:angiogenesis involved in wound healing; IEP:RGD.
 GO:0048870; P:cell motility; IEA:Compara.
 GO:0070301; P:cellular response to hydrogen peroxide; IEP:RGD.
 GO:0060206; P:estrous cycle phase; IEP:RGD.
 GO:0007565; P:female pregnancy; IEP:RGD.
 GO:0021854; P:hypothalamus development; IEP:RGD.
 GO:0006917; P:induction of apoptosis; IEA:Compara.
 GO:0045786; P:negative regulation of cell cycle; IEA:Compara.
 GO:0021983; P:pituitary gland development; IEP:RGD.
 GO:0030578; P:PML body organization; IEA:Compara.
 GO:0045766; P:positive regulation of angiogenesis; IMP:RGD.
 GO:0008284; P:positive regulation of cell proliferation; IMP:RGD.
 GO:0010595; P:positive regulation of endothelial cell migration; ISS:UniProtKB.
 GO:0045648; P:positive regulation of erythrocyte differentiation; ISS:UniProtKB.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.
 GO:0010715; P:regulation of extracellular matrix disassembly; IMP:RGD.
 GO:0046677; P:response to antibiotic; IEA:Compara.
 GO:0032355; P:response to estradiol stimulus; IEP:RGD.
 GO:0001666; P:response to hypoxia; IEP:RGD.
 GO:0070555; P:response to interleukin-1; IEP:RGD.
 GO:0034616; P:response to laminar fluid shear stress; IEP:RGD.
 GO:0009612; P:response to mechanical stimulus; IEP:RGD.
 GO:0006366; P:transcription from RNA polymerase II promoter; IEA:Compara. 
Interpro
 IPR000418; Ets_dom.
 IPR003118; Pointed_dom.
 IPR013761; SAM/pointed.
 IPR016311; Transform_prot_C-ets.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF00178; Ets
 PF02198; SAM_PNT 
SMART
 SM00413; ETS
 SM00251; SAM_PNT 
PROSITE
 PS00345; ETS_DOMAIN_1
 PS00346; ETS_DOMAIN_2
 PS50061; ETS_DOMAIN_3
 PS51433; PNT 
PRINTS
 PR00454; ETSDOMAIN.