CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030517
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, isoform CRA_a 
Protein Synonyms/Alias
 Inhibitor of nuclear factor kappa-B kinase subunit beta; cDNA FLJ33978 fis, clone DFNES2004354, highly similar to Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) 
Gene Name
 IKBKB 
Gene Synonyms/Alias
 hCG_17395 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
78YGPNGCFKALDDILNubiquitination[1]
114DESLQSLKARIQQDTubiquitination[1]
195SCILQEPKRNLAFFQubiquitination[1]
332QRSPMGRKQGGTLDDubiquitination[1, 2]
480NSLPEPAKKSEELVAubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Kinase; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 533 AA 
Protein Sequence
MSSDGTIRHS KVRQKSEVDI VVSEDLNGTV KFSSSLPYPN NLNSVLAERL EKWLQLMLMW 60
HPRQRGTDPT YGPNGCFKAL DDILNLKLVH ILNMVTGTIH TYPVTEDESL QSLKARIQQD 120
TGIPEEDQEL LQEAGLALIP DKPATQCISD GKLNEGHTLD MDLVFLFDNS KITYETQISP 180
RPQPESVSCI LQEPKRNLAF FQLRKVWGQV WHSIQTLKED CNRLQQGQRA AMMNLLRNNS 240
CLSKMKNSMA SMSQQLKAKL DFFKTSIQID LEKYSEQTEF GITSDKLLLA WREMEQAVEL 300
CGRENEVKLL VERMMALQTD IVDLQRSPMG RKQGGTLDDL EEQARELYRR LREKPRDQRT 360
EGDSQEMVRL LLQAIQSFEK KVRVIYTQLS KTVVCKQKAL ELLPKVEEVV SLMNEDEKTV 420
VRLQEKRQKE LWNLLKIACS KVRGPVSGSP DSMNASRLSQ PGQLMSQPST ASNSLPEPAK 480
KSEELVAEAH NLCTLLENAI QDTVREQDQS FTALDWSWLQ TEEEEHSCLE QAS 533 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0008384; F:IkappaB kinase activity; IEA:InterPro.
 GO:0007252; P:I-kappaB phosphorylation; IEA:GOC. 
Interpro
 IPR022007; IKKbetaNEMObind.
 IPR019955; Ubiquitin_supergroup. 
Pfam
 PF12179; IKKbetaNEMObind 
SMART
  
PROSITE
 PS50053; UBIQUITIN_2 
PRINTS