CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015401
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Myosin-14 
Protein Synonyms/Alias
 Myosin heavy chain 14; Myosin heavy chain, non-muscle IIc; Non-muscle myosin heavy chain IIc; NMHC II-C 
Gene Name
 Myh14 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
437YVQKAQTKEQADFALubiquitination[1]
679RTVGQLYKESLSRLMubiquitination[1]
884ARAQELQKVQELQQQubiquitination[1]
1895QVRDQLEKSNLRLKQubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping (By similarity). 
Sequence Annotation
 DOMAIN 17 806 Myosin head-like.
 DOMAIN 807 836 IQ.
 NP_BIND 194 201 ATP (Potential).
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 1466 1466 Phosphothreonine.
 MOD_RES 1973 1973 Phosphoserine (By similarity).  
Keyword
 Acetylation; Actin-binding; Alternative splicing; ATP-binding; Calmodulin-binding; Cell shape; Coiled coil; Complete proteome; Direct protein sequencing; Motor protein; Myosin; Nucleotide-binding; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2000 AA 
Protein Sequence
MAAVTMSVSG RKVASRPGPV PEAAQSFLYA PRTPNVGGPG GPQVEWTARR MVWVPSELHG 60
FEAAALRDEG EEEAEVELAE SGRRLRLPRD QIQRMNPPKF SKAEDMAELT CLNEASVLHN 120
LRERYYSGLI YTYSGLFCVV INPYKQLPIY TEAIVEMYRG KKRHEVPPHV YAVTEGAYRS 180
MLQDREDQSI LCTGESGAGK TENTKKVIQY LAHVASSPKG RKEPGVPASV STMSYGELER 240
QLLQANPILE AFGNAKTVKN DNSSRFGKFI RINFDIAGYI VGANIETYLL EKSRAIRQAK 300
DECSFHIFYQ LLGGAGEQLK ADLLLEPCSH YRFLTNGPSS SPGQERELFQ ETLESLRVLG 360
LLPEEITAML RTVSAVLQFG NIVLKKERNT DQATMPDNTA AQKLCRLLGL GVTDFSRALL 420
TPRIKVGRDY VQKAQTKEQA DFALEALAKA TYERLFRWLV LRLNRALDRS PRQGASFLGI 480
LDIAGFEIFQ LNSFEQLCIN YTNEKLQQLF NHTMFVLEQE EYQREGIPWT FLDFGLDLQP 540
CIDLIERPAN PPGLLALLDE ECWFPKATDK SFVEKVAQEQ GSHPKFQRPR NLRDQADFSV 600
LHYAGKVDYK ASEWLMKNMD PLNDNVAALL HQSTDRLTAE IWKDVEGIVG LEQVSSLGDG 660
PPGGRPRRGM FRTVGQLYKE SLSRLMATLS NTNPSFVRCI VPNHEKRAGK LEPRLVLDQL 720
RCNGVLEGIR ICRQGFPNRI LFQEFRQRYE ILTPNAIPKG FMDGKQACEK MIQALELDPN 780
LYRVGQSKIF FRAGVLAQLE EERDLKVTDI IVSFQAAARG YLARRAFQRR QQQQSALRVM 840
QRNCAAYLKL RNWQWWRLFI KVKPLLQVTR QDEVLQARAQ ELQKVQELQQ QSAREVGELQ 900
GRVAQLEEER TRLAEQLRAE AELCSEAEET RARLAARKQE LELVVTELEA RVGEEEECSR 960
QLQSEKKRLQ QHIQELESHL EAEEGARQKL QLEKVTTEAK MKKFEEDLLL LEDQNSKLSK 1020
ERRLLEERLA EFSSQAAEEE EKVKSLNKLR LKYEATISDM EDRLKKEEKG RQELEKLKRR 1080
LDGESSELQE QMVEQKQRAE ELLAQLGRKE DELQAALLRA EEEGGARAQL LKSLREAQAG 1140
LAEAQEDLEA ERVARAKAEK QRRDLGEELE ALRGELEDTL DSTNAQQELR SKREQEVTEL 1200
KKALEEESRA HEVSMQELRQ RHSQALVEMA EQLEQARRGK GVWEKTRLSL EAEVSELKAE 1260
LSSLQTSRQE GEQKRRRLES QLQEVQGRSS DSERARSEAA EKLQRAQAEL ESVSTALSEA 1320
ESKAIRLGKE LSSAESQLHD TQELLQEETR AKLALGSRVR ALEAEAAGLR EQMEEEVVAR 1380
ERAGRELQST QAQLSEWRRR QEEEAAVLEA GEEARRRAAR EAETLTQRLA EKTEAVERLE 1440
RARRRLQQEL DDATVDLGQQ KQLLSTLEKK QRKFDQLLAE EKAAVLRAVE DRERIEAEGR 1500
EREARALSLT RALEEEQEAR EELERQNRAL RAELEALLSS KDDVGKNVHE LERARKAAEQ 1560
AASDLRTQVT ELEDELTAAE DAKLRLEVTV QALKAQHERD LQGRDDAGEE RRRQLAKQLR 1620
DAEVERDEER KQRALAMAAR KKLELELEEL KAQTSAAGQG KEEAVKQLKK MQVQMKELWR 1680
EVEETRSSRD EMFTLSRENE KKLKGLEAEV LRLQEELAAS DRARRQAQQD RDEMAEEVAS 1740
GNLSKAATLE EKRQLEGRLS QLEEELEEEQ NNSELLKDHY RKLVLQVESL TTELSAERSF 1800
SAKAESGRQQ LERQIQELRA RLGEEDAGAR ARQKMLIAAL ESKLAQAEEQ LEQESRERIL 1860
SGKLVRRAEK RLKEVVLQVD EERRVADQVR DQLEKSNLRL KQLKRQLEEA EEEASRAQAG 1920
RRRLQRELED VTESAESMNR EVTTLRNRLR RGPLTFTTRT VRQVFRLEEG VASDEEEAEG 1980
AEPGSAPGQE PEAPPPATPQ 2000 
Gene Ontology
 GO:0030424; C:axon; IDA:MGI.
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0030426; C:growth cone; IDA:MGI.
 GO:0016459; C:myosin complex; IDA:MGI.
 GO:0001725; C:stress fiber; IDA:MGI.
 GO:0051015; F:actin filament binding; IDA:MGI.
 GO:0030898; F:actin-dependent ATPase activity; IDA:MGI.
 GO:0005524; F:ATP binding; IDA:MGI.
 GO:0000146; F:microfilament motor activity; IDA:MGI.
 GO:0030048; P:actin filament-based movement; IDA:MGI.
 GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW. 
Interpro
 IPR000048; IQ_motif_EF-hand-BS.
 IPR027401; Myosin-like_IQ_dom.
 IPR001609; Myosin_head_motor_dom.
 IPR004009; Myosin_N.
 IPR002928; Myosin_tail.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00063; Myosin_head
 PF02736; Myosin_N
 PF01576; Myosin_tail_1 
SMART
 SM00015; IQ
 SM00242; MYSc 
PROSITE
 PS50096; IQ 
PRINTS
 PR00193; MYOSINHEAVY.