UniProt Accession

 CSRP2_HUMAN; Q16527; Q93030 

Genbank Protein ID

 U46006; U57646; U95018; BT019913; BC000992 

Genbank Nucleotide ID

 AAC27344.1; AAC51753.1; AAC51755.1; AAV38716.1; AAH00992.1 

Protein Name

 Cysteine and glycine-rich protein 2 

Protein Synonyms/Alias

 Cysteine-rich protein 2; CRP2; LIM domain only protein 5; LMO-5; Smooth muscle cell LIM protein; SmLIM 

Gene Name

 CSRP2 

Gene Synonyms/Alias

 LMO5; SMLIM 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
65	CKSCYGKKYGPKGYG	ubiquitination	[1, 2]
69	YGKKYGPKGYGYGQG	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system. 

Sequence Annotation

 DOMAIN 10 61 LIM zinc-binding 1.
 DOMAIN 119 170 LIM zinc-binding 2.
 MOTIF 64 69 Nuclear localization signal (Potential).  

Keyword

 Complete proteome; Developmental protein; Differentiation; LIM domain; Metal-binding; Nucleus; Reference proteome; Repeat; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 193 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; NAS:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0030154; P:cell differentiation; NAS:UniProtKB.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. 

Interpro

 IPR001781; Znf_LIM. 

Pfam

 PF00412; LIM 

SMART

 SM00132; LIM 

PROSITE

 PS00478; LIM_DOMAIN_1
 PS50023; LIM_DOMAIN_2 

PRINTS