UniProt Accession

 MANF_HUMAN; P55145; Q14CX4; Q86U67; Q96IS4 

Genbank Protein ID

 M83751; BT007110; AC092037; BC007282; BC113588; BC113590 

Genbank Nucleotide ID

 AAB08753.1; AAP35774.1; AAH07282.1; AAI13589.1; AAI13591.1 

Protein Name

 Mesencephalic astrocyte-derived neurotrophic factor 

Protein Synonyms/Alias

 Arginine-rich protein; Protein ARMET 

Gene Name

 MANF 

Gene Synonyms/Alias

 ARMET; ARP 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
45	GRFYQDLKDRDVTFS	ubiquitination	[1]
94	KIINEVSKPLAHHIP	acetylation	[2, 3]
94	KIINEVSKPLAHHIP	ubiquitination	[4]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. 

Sequence Annotation

 MOD_RES 76 76 Phosphotyrosine (By similarity).
 DISULFID 30 117
 DISULFID 33 106
 DISULFID 64 75
 DISULFID 151 154  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Growth factor; Phosphoprotein; Reference proteome; Secreted; Sialic acid; Signal; Unfolded protein response. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 182 AA 

Protein Sequence

Gene Ontology

 GO:0005615; C:extracellular space; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0006986; P:response to unfolded protein; IEA:UniProtKB-KW.
 GO:0002014; P:vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure; IEA:Compara. 

Interpro

 IPR019345; Armet_prot.
 IPR011001; Saposin-like. 

Pfam

 PF10208; Armet 

SMART

  

PROSITE

  

PRINTS