CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016844
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein LSM14 homolog B 
Protein Synonyms/Alias
 Protein FAM61B; RNA-associated protein 55B; mRAP55B 
Gene Name
 Lsm14b 
Gene Synonyms/Alias
 Fam61b; Rap55b 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
19SKISLISKAQIRYEGacetylation[1]
327DNISSELKTSSRRTTubiquitination[2]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 May play a role in control of mRNA translation (By similarity). 
Sequence Annotation
 DOMAIN 241 277 DFDF.
 MOTIF 310 326 FFD box.
 MOTIF 330 350 TFG box.
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 106 106 Phosphoserine (By similarity).
 MOD_RES 115 115 Phosphoserine (By similarity).
 MOD_RES 154 154 Phosphoserine (By similarity).  
Keyword
 Acetylation; Complete proteome; Developmental protein; Phosphoprotein; Reference proteome; Ribonucleoprotein; Translation regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 385 AA 
Protein Sequence
MSGSSGTPYL GSKISLISKA QIRYEGILYT IDTDNSTVAL AKVRSFGTED RPTDRPAPPR 60
EEIYEYIIFR GSDIKDITVC EPPKAQHTLP QDPAIVQSSL GSASASPFQP HVPYSPFRGM 120
PPYGQLAASS LLSQQYAASL GLGAGFPSTP VGKSPMVEQA VQTSSVDNLN AKKLLPSKVT 180
SATQLNGRQA QPSSKPASDV VQPAPVHTQG QVNDENRRPP RRRSGNRRTR NRSRGQNRPT 240
NVKENTIKFE GDFDFESANA QFNREELDKE FKKKLNFKDD KADKGEEKDP AVMAQSEETA 300
AEEDLLGPNC YYDKSKSFFD NISSELKTSS RRTTWAEERK LNTETFGVSG RFLRGRSSRG 360
GFRGGRGNGT TRRNPTSHRA GTGRV 385 
Gene Ontology
 GO:0030529; C:ribonucleoprotein complex; IEA:UniProtKB-KW.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
 GO:0006417; P:regulation of translation; IEA:UniProtKB-KW. 
Interpro
 IPR025762; DFDF.
 IPR019050; FDF_dom.
 IPR025761; FFD_box.
 IPR025609; Lsm14_N.
 IPR010920; LSM_dom.
 IPR025768; TFG_box. 
Pfam
 PF09532; FDF
 PF12701; LSM14 
SMART
  
PROSITE
 PS51512; DFDF
 PS51513; FFD
 PS51536; TFG 
PRINTS