CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037485
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Pantothenate kinase 4 
Protein Synonyms/Alias
  
Gene Name
 PANK4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
195ALLTKTKKFDELLHLubiquitination[1, 2]
239LIASSFGKSATADQEubiquitination[3, 4]
249TADQEFSKEDMAKSLubiquitination[2, 3]
448FRQKYWNKLQTLRQQubiquitination[1, 2]
551YFGFEEAKRKLQERPubiquitination[2, 3]
668LDLSRLDKGLAALVRubiquitination[2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 734 AA 
Protein Sequence
MAECGASGSG SSGDSLDKSI TLPPDEIFRN LENAKRFAID IGGSLTKLAY YSTVQHKVAK 60
VRSFDHSGKD TEREHEPPYE ISVQEEITAR LHFIKFENTY IEACLDFIKD HLVNTETKVI 120
QATGGGAFVY QKDSDPEFRF QTNHPHIFPY LLVNIGSGVS IVKVETEDRF EWVGGSSIGG 180
GTFWGLGALL TKTKKFDELL HLASRGQHSN VDMLVRDVYG GAHQTLGLSG NLIASSFGKS 240
ATADQEFSKE DMAKSLLHMI SNDIGQLACL HARLHSLDRV YFGGFFIRGH PVTMRTITYS 300
INFFSKGEVQ ALFLRHEGYL GAIGAFLKGA EQDNPNQYSW GENYAGSSGL MSASPELGPA 360
QRARSGTFDL LEMDRLERPL VDLPLLLDPP SYVPDTVDLT DDALARKYWL TCFEEALDGV 420
VKRAVASQPD SVDAAERAEK FRQKYWNKLQ TLRQQPFAYG TLTVRSLLDT REHCLNEFNF 480
PDPYSKVKQR ENGVALRCFP GVVRSLDALG WEERQLALVK GLLAGNVFDW GAKAVSAVLE 540
SDPYFGFEEA KRKLQERPWL VDSYSEWLQR LKGPPHKCAL IFADNSGIDI ILGVFPFVRE 600
LLLRGTEVIL ACNSGPALND VTHSESLIVA ERIAGMDPVV HSALQEERLL LVQTGSSSPC 660
LDLSRLDKGL AALVRERGAD LVVIEGMGRA VHTNYHAALR CESLKLAVIK NAWLAERLGG 720
RLFSVIFKYE VPAE 734 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004594; F:pantothenate kinase activity; IEA:InterPro.
 GO:0015937; P:coenzyme A biosynthetic process; IEA:InterPro. 
Interpro
 IPR002791; DUF89.
 IPR015844; PanK_long.
 IPR004567; Type_II_PanK. 
Pfam
 PF01937; DUF89
 PF03630; Fumble 
SMART
  
PROSITE
  
PRINTS