CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042401
UniProt Accession
Genbank Protein ID
 U07000 
Genbank Nucleotide ID
  
Protein Name
 Breakpoint cluster region protein 
Protein Synonyms/Alias
  
Gene Name
 BCR 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
129SLETLLYKPVDRVTRubiquitination[1]
146LVLHDLLKHTPASHPubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 257 AA 
Protein Sequence
ALESTKASEL DLEKGLEMRK WVLSGILASE ETYLSHLEAL LLPMKPLKAA ATTSQPVLTS 60
QQIETIFFKV PELYEIHKEF YDGLFPRVQQ WSHQQRVGDL FQKLNLRARS NKDAKDPTTK 120
NSLETLLYKP VDRVTRSTLV LHDLLKHTPA SHPDHPLLQD ALRISQNFLS SINEEITPRR 180
QSMTVKKGEH RQLLKDSFMV ELVEGARKLR HVFLFTDLLL CTKLKKQSGG KTQQYDCKWY 240
IPLTDLSFQM VDELEAV 257 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. 
Interpro
 IPR000219; DH-domain.
 IPR001331; GDS_CDC24_CS.
 IPR011993; PH_like_dom. 
Pfam
 PF00621; RhoGEF 
SMART
 SM00325; RhoGEF 
PROSITE
 PS00741; DH_1
 PS50010; DH_2 
PRINTS