UniProt Accession

 RS6A_YEAST; P0CX37; D6VQH5; P02365; P05751; Q02894 

Genbank Protein ID

 X02746; U43281; BK006949 

Genbank Nucleotide ID

 CAA26525.1; AAB68209.1; DAA11343.1 

Protein Name

 40S ribosomal protein S6-A 

Protein Synonyms/Alias

 RP9; S10; YS4 

Gene Name

 RPS6A 

Gene Synonyms/Alias

 RPS101; RPS10B; YPL090C; LPG18C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
2	******MKLNISYPV	ubiquitination	[1]
14	YPVNGSQKTFEIDDE	ubiquitination	[1]
46	EAVGDEFKGYVFKIS	acetylation	[2]
46	EAVGDEFKGYVFKIS	ubiquitination	[1]
51	EFKGYVFKISGGNDK	acetylation	[2]
58	KISGGNDKQGFPMKQ	ubiquitination	[1]
64	DKQGFPMKQGVLLPT	ubiquitination	[1]
79	RIKLLLTKNVSCYRP	acetylation	[2]
79	RIKLLLTKNVSCYRP	ubiquitination	[1]
116	LALVIVKKGEQELEG	acetylation	[3]
116	LALVIVKKGEQELEG	ubiquitination	[1]
131	LTDTTVPKRLGPKRA	ubiquitination	[1]
143	KRANNIRKFFGLSKE	acetylation	[2]
143	KRANNIRKFFGLSKE	ubiquitination	[1]
149	RKFFGLSKEDDVRDF	acetylation	[2]
149	RKFFGLSKEDDVRDF	ubiquitination	[1]
167	REVTKGEKTYTKAPK	acetylation	[2]
171	KGEKTYTKAPKIQRL	acetylation	[2]
171	KGEKTYTKAPKIQRL	ubiquitination	[1]
214	EYAQLLAKRLSERKA	acetylation	[2]
214	EYAQLLAKRLSERKA	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [3] Preparative peptide isoelectric focusing as a tool for improving the identification of lysine-acetylated peptides from complex mixtures.
 Xie H, Bandhakavi S, Roe MR, Griffin TJ.
 J Proteome Res. 2007 May;6(5):2019-26. [PMID: 17397211] 

Functional Description

 Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. 

Sequence Annotation

 MOD_RES 163 163 Phosphothreonine.  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleus; Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosomal protein; Ribosome biogenesis; rRNA processing. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 236 AA 

Protein Sequence

Gene Ontology

 GO:0030686; C:90S preribosome; IDA:SGD.
 GO:0022627; C:cytosolic small ribosomal subunit; IDA:SGD.
 GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
 GO:0032040; C:small-subunit processome; IDA:SGD.
 GO:0003735; F:structural constituent of ribosome; IDA:SGD.
 GO:0002181; P:cytoplasmic translation; IC:SGD.
 GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IGI:SGD. 

Interpro

 IPR014401; Ribosomal_S6_euk.
 IPR001377; Ribosomal_S6e.
 IPR018282; Ribosomal_S6e_CS. 

Pfam

 PF01092; Ribosomal_S6e 

SMART

  

PROSITE

 PS00578; RIBOSOMAL_S6E 

PRINTS