CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016926
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 DNA mismatch repair protein MutL 
Protein Synonyms/Alias
  
Gene Name
 mutL 
Gene Synonyms/Alias
 LA_1175 
Created Date
 July 27, 2013 
Organism
 Leptospira interrogans serogroup Icterohaemorrhagiae serovar La 
NCBI Taxa ID
 189518 
Lysine Modification
Position
Peptide
Type
References
546ACRSAIKKGDQLSDPmethylation[1]
Reference
 [1] High-coverage proteome analysis reveals the first insight of protein modification systems in the pathogenic spirochete Leptospira interrogans.
 Cao XJ, Dai J, Xu H, Nie S, Chang X, Hu BY, Sheng QH, Wang LS, Ning ZB, Li YX, Guo XK, Zhao GP, Zeng R.
 Cell Res. 2010 Feb;20(2):197-210. [PMID: 19918266] 
Functional Description
 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; DNA damage; DNA repair; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 593 AA 
Protein Sequence
MGKIQELSPE LINQIAAGEV IESAHSVVKE LMENSMDASA TQVDVESKDG GLSLLRITDN 60
GTGIEPEDLE PALKRHATSK IQDYKDLESV LSYGFRGEAL ASIASVSRLT LESGTKEQKT 120
AWKTRSVAGK ISEKEEIPGF IGTKILVEEL FFNTPVRRKF LKSIRSEDKK IRDRVTTQAL 180
AREDVRFRLF QDGKEVFVLP TRENKKERII DLFGENFRDH LLEVSLERGG IQATGYISDP 240
DFYKSNRTGQ FIFINGRPIE IKYSSVLLKK AYDELLPPNG HPYCFLFFEI DPSRVDVNVH 300
PAKREIRFLD EDGFNGFFLA LIQKELRSST PVSFLELKKR LLKPAPETHS TTSFYQARSS 360
GKNPLLGREL FSGVSKQEGF ELDRMGPGVS LSELTDERVK HSSFVPKKHF GVLFETFILA 420
EAEDGFYIID QHTAHERIRY EEVLRKLEKR NYGIQPLLTP IRIDVSKQEQ EDILNRKKEY 480
EEVGIFLDPL GEDSIVLREI PAYMEPGQEK EIVLDFLNRT EGKETSEPEL YDLMAKCVAC 540
RSAIKKGDQL SDPILAEILN RLSYCENPSR CPHGRPTLVK LSRDDLERMF HRK 593 
Gene Ontology
 GO:0032300; C:mismatch repair complex; IBA:RefGenome.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0016887; F:ATPase activity; IBA:RefGenome.
 GO:0030983; F:mismatched DNA binding; IEA:InterPro.
 GO:0003697; F:single-stranded DNA binding; IBA:RefGenome.
 GO:0006298; P:mismatch repair; IBA:RefGenome. 
Interpro
 IPR002099; DNA_mismatch_repair.
 IPR013507; DNA_mismatch_repair_C.
 IPR014762; DNA_mismatch_repair_CS.
 IPR020667; DNA_mismatch_repair_MutL.
 IPR014763; DNA_mismatch_repair_N.
 IPR003594; HATPase_ATP-bd.
 IPR014790; MutL_C.
 IPR020568; Ribosomal_S5_D2-typ_fold.
 IPR014721; Ribosomal_S5_D2-typ_fold_subgr. 
Pfam
 PF01119; DNA_mis_repair
 PF08676; MutL_C 
SMART
 SM00387; HATPase_c
 SM00853; MutL_C 
PROSITE
 PS00058; DNA_MISMATCH_REPAIR_1 
PRINTS