CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014145
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 SPRY domain-containing protein 7 
Protein Synonyms/Alias
 Chronic lymphocytic leukemia deletion region gene 6 protein; CLL deletion region gene 6 protein 
Gene Name
 SPRYD7 
Gene Synonyms/Alias
 C13orf1; CLLD6 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
85GIGVATQKVNLNQIPubiquitination[1, 2, 3, 4, 5]
115LYHNNEEKNRLPANSubiquitination[2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
  
Sequence Annotation
 DOMAIN 1 184 B30.2/SPRY.  
Keyword
 Alternative splicing; Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 196 AA 
Protein Sequence
MATSVLCCLR CCRDGGTGHI PLKEMPAVQL DTQHMGTDVV IVKNGRRICG TGGCLASAPL 60
HQNKSYFEFK IQSTGIWGIG VATQKVNLNQ IPLGRDMHSL VMRNDGALYH NNEEKNRLPA 120
NSLPQEGDVV GITYDHVELN VYLNGKNMHC PASGIRGTVY PVVYVDDSAI LDCQFSEFYH 180
TPPPGFEKIL FEQQIF 196 
Gene Ontology
  
Interpro
 IPR001870; B30.2/SPRY.
 IPR008985; ConA-like_lec_gl_sf.
 IPR018355; SPla/RYanodine_receptor_subgr.
 IPR003877; SPRY_rcpt. 
Pfam
 PF00622; SPRY 
SMART
 SM00449; SPRY 
PROSITE
 PS50188; B302_SPRY 
PRINTS