UniProt Accession

 DSCAM_HUMAN; O60469; O60468 

Genbank Protein ID

 AF023450; AF023449; AF217525; AL163283; AL163282; AL163281 

Genbank Nucleotide ID

 AAC17967.1; AAC17966.1; AAF27525.1; CAB90464.1; CAB90436.1; CAB90444.1 

Protein Name

 Down syndrome cell adhesion molecule 

Protein Synonyms/Alias

 CHD2 

Gene Name

 DSCAM 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
1641	LAEMLMSKNTRTSDT	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies. Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. In spinal chord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding. Enhances netrin-induced phosphorylation of PAK1 and FYN. Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38. 

Sequence Annotation

 DOMAIN 39 129 Ig-like C2-type 1.
 DOMAIN 125 216 Ig-like C2-type 2.
 DOMAIN 225 305 Ig-like C2-type 3.
 DOMAIN 313 401 Ig-like C2-type 4.
 DOMAIN 407 500 Ig-like C2-type 5.
 DOMAIN 504 592 Ig-like C2-type 6.
 DOMAIN 596 685 Ig-like C2-type 7.
 DOMAIN 690 783 Ig-like C2-type 8.
 DOMAIN 787 883 Ig-like C2-type 9.
 DOMAIN 885 978 Fibronectin type-III 1.
 DOMAIN 984 1082 Fibronectin type-III 2.
 DOMAIN 1088 1183 Fibronectin type-III 3.
 DOMAIN 1189 1279 Fibronectin type-III 4.
 DOMAIN 1285 1377 Ig-like C2-type 10.
 DOMAIN 1376 1470 Fibronectin type-III 5.
 DOMAIN 1476 1566 Fibronectin type-III 6.
 CARBOHYD 28 28 N-linked (GlcNAc...) (Potential).
 CARBOHYD 78 78 N-linked (GlcNAc...) (Potential).
 CARBOHYD 470 470 N-linked (GlcNAc...) (Potential).
 CARBOHYD 487 487 N-linked (GlcNAc...) (Potential).
 CARBOHYD 512 512 N-linked (GlcNAc...) (Potential).
 CARBOHYD 556 556 N-linked (GlcNAc...) (Potential).
 CARBOHYD 658 658 N-linked (GlcNAc...) (Potential).
 CARBOHYD 666 666 N-linked (GlcNAc...) (Potential).
 CARBOHYD 710 710 N-linked (GlcNAc...) (Potential).
 CARBOHYD 748 748 N-linked (GlcNAc...) (Potential).
 CARBOHYD 795 795 N-linked (GlcNAc...) (Potential).
 CARBOHYD 924 924 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1142 1142 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1160 1160 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1250 1250 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1271 1271 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1341 1341 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1488 1488 N-linked (GlcNAc...) (Potential).
 DISULFID 46 102 By similarity.
 DISULFID 145 197 By similarity.
 DISULFID 246 293 By similarity.
 DISULFID 335 385 By similarity.
 DISULFID 428 484 By similarity.
 DISULFID 525 575 By similarity.
 DISULFID 617 669 By similarity.
 DISULFID 711 766 By similarity.
 DISULFID 809 865 By similarity.
 DISULFID 1307 1359 By similarity.  

Keyword

 Alternative splicing; Cell adhesion; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Neurogenesis; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Secreted; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 2012 AA 

Protein Sequence

Gene Ontology

 GO:0030424; C:axon; ISS:UniProtKB.
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0030426; C:growth cone; ISS:UniProtKB.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0007155; P:cell adhesion; TAS:ProtInc.
 GO:0048813; P:dendrite morphogenesis; IEA:Compara.
 GO:0070593; P:dendrite self-avoidance; ISS:UniProtKB.
 GO:0007626; P:locomotory behavior; IEA:Compara.
 GO:0007162; P:negative regulation of cell adhesion; ISS:UniProtKB.
 GO:0048842; P:positive regulation of axon extension involved in axon guidance; IDA:UniProtKB.
 GO:0042327; P:positive regulation of phosphorylation; IDA:UniProtKB.
 GO:0060060; P:post-embryonic retina morphogenesis in camera-type eye; IEA:Compara. 

Interpro

 IPR003961; Fibronectin_type3.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003599; Ig_sub.
 IPR003598; Ig_sub2. 

Pfam

 PF00041; fn3
 PF07679; I-set 

SMART

 SM00060; FN3
 SM00409; IG
 SM00408; IGc2 

PROSITE

 PS50853; FN3
 PS50835; IG_LIKE 

PRINTS