| Tag | Content |
|---|
| CPLM ID | CPLM-008425 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | H(+)/Cl(-) exchange transporter 5 |
Protein Synonyms/Alias | Chloride channel protein 5; ClC-5; Chloride transporter ClC-5 |
Gene Name | CLCN5 |
Gene Synonyms/Alias | CLCK2 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 579 | AKEEFAHKTLAMDVM | ubiquitination | [1] | | 649 | ISIENARKKQDGVVS | ubiquitination | [1] |
|
Reference | [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C. Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [ PMID: 21890473] |
Functional Description | Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function. |
Sequence Annotation | DOMAIN 586 650 CBS 1.
DOMAIN 682 742 CBS 2.
NP_BIND 617 619 ATP.
NP_BIND 724 727 ATP.
MOTIF 167 171 Selectivity filter part_1 (By
MOTIF 209 213 Selectivity filter part_2 (By
MOTIF 453 457 Selectivity filter part_3 (By
BINDING 168 168 Chloride (By similarity).
BINDING 455 455 Chloride; via amide nitrogen (By
BINDING 558 558 Chloride (By similarity).
BINDING 596 596 ATP; via amide nitrogen and carbonyl |
Keyword | 3D-structure; Alternative splicing; Antiport; ATP-binding; CBS domain; Cell membrane; Chloride; Complete proteome; Disease mutation; Endosome; Golgi apparatus; Ion transport; Membrane; Nucleotide-binding; Polymorphism; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 746 AA |
Protein Sequence | MDFLEEPIPG VGTYDDFNTI DWVREKSRDR DRHREITNKS KESTWALIHS VSDAFSGWLL 60
MLLIGLLSGS LAGLIDISAH WMTDLKEGIC TGGFWFNHEH CCWNSEHVTF EERDKCPEWN 120
SWSQLIISTD EGAFAYIVNY FMYVLWALLF AFLAVSLVKV FAPYACGSGI PEIKTILSGF 180
IIRGYLGKWT LVIKTITLVL AVSSGLSLGK EGPLVHVACC CGNILCHCFN KYRKNEAKRR 240
EVLSAAAAAG VSVAFGAPIG GVLFSLEEVS YYFPLKTLWR SFFAALVAAF TLRSINPFGN 300
SRLVLFYVEF HTPWHLFELV PFILLGIFGG LWGALFIRTN IAWCRKRKTT QLGKYPVIEV 360
LVVTAITAIL AFPNEYTRMS TSELISELFN DCGLLDSSKL CDYENRFNTS KGGELPDRPA 420
GVGVYSAMWQ LALTLILKIV ITIFTFGMKI PSGLFIPSMA VGAIAGRLLG VGMEQLAYYH 480
QEWTVFNSWC SQGADCITPG LYAMVGAAAC LGGVTRMTVS LVVIMFELTG GLEYIVPLMA 540
AAMTSKWVAD ALGREGIYDA HIRLNGYPFL EAKEEFAHKT LAMDVMKPRR NDPLLTVLTQ 600
DSMTVEDVET IISETTYSGF PVVVSRESQR LVGFVLRRDL IISIENARKK QDGVVSTSII 660
YFTEHSPPLP PYTPPTLKLR NILDLSPFTV TDLTPMEIVV DIFRKLGLRQ CLVTHNGRLL 720
GIITKKDVLK HIAQMANQDP DSILFN 746 |
Gene Ontology | GO:0045177; C:apical part of cell; IDA:UniProtKB. GO:0010008; C:endosome membrane; TAS:Reactome. GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell. GO:0005887; C:integral to plasma membrane; TAS:ProtInc. GO:0015297; F:antiporter activity; IEA:UniProtKB-KW. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0005254; F:chloride channel activity; TAS:ProtInc. GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro. GO:0006897; P:endocytosis; IEA:Compara. GO:0007588; P:excretion; TAS:ProtInc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |