CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032022
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Kinesin-like protein KIFC3 
Protein Synonyms/Alias
 cDNA FLJ56036, highly similar to Homo sapiens kinesin family member C3 (KIFC3), mRNA 
Gene Name
 KIFC3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
83RLRTGRGKDTPVCGDubiquitination[1]
408TNDYNGLKRQVRGFPubiquitination[1]
508IHLLHKGKPVSFELDubiquitination[2]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Microtubule; Motor protein; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 848 AA 
Protein Sequence
MCASACKDTA AWCPEEAAEP QAMVPSRRTW NLGATPSLRG LWRVGRAPEP EPGMARPAPA 60
PASPAARPFP HTGPGRLRTG RGKDTPVCGD EDSSARSAAR PALAQCRALS VDWAGPGSPH 120
GLYLTLQVEH LKEKLISQAQ EVSRLRSELG GTDLEKHRDL LMVENERLRQ EMRRCEAELQ 180
ELRTKPAGPC PGCEHSQESA QLRDKLSQLQ LEMAESKGML SELNLEVQQK TDRLAEVELR 240
LKDCLAEKAQ EEERLSRRLR DSHETIASLR AQSPPVKYVI KTVEVESSKT KQALSESQAR 300
NQHLQEQVAM QRQVLKEMEQ QLQSSHQLTA RLRAQIAMYE SELERAHGQM LEEMQSLEED 360
KNRAIEEAFA RAQVEMKAVH ENLAGVRTNL LTLQPALRTL TNDYNGLKRQ VRGFPLLLQE 420
ALRSVKAEIG QAIEEVNSNN QELLRKYRRE LQLRKKCHNE LVRLKGNIRV IARVRPVTKE 480
DGEGPEATNA VTFDADDDSI IHLLHKGKPV SFELDKVFSP QASQQDVFQE VQALVTSCID 540
GFNVCIFAYG QTGAGKTYTM EGTAENPGIN QRALQLLFSE VQEKASDWEY TITVSAAEIY 600
NEVLRDLLGK EPQEKLEIRL CPDGSGQLYV PGLTEFQVQS VDDINKVFEF GHTNRTTEFT 660
NLNEHSSRSH ALLIVTVRGV DCSTGLRTTG KLNLVDLAGS ERVGKSGAEG SRLREAQHIN 720
KSLSALGDVI AALRSRQGHV PFRNSKLTYL LQDSLSGDSK TLMVVQVSPV EKNTSETLYS 780
LKFAERVRSV ELGPGLRRAE LGSWSSQEHL EWEPACQTPQ PSARAHSAPS SGTSSRPGSI 840
RRKLQPSA 848 
Gene Ontology
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005875; C:microtubule associated complex; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
 GO:0007018; P:microtubule-based movement; IEA:InterPro. 
Interpro
 IPR027325; KIFC3.
 IPR019821; Kinesin_motor_CS.
 IPR001752; Kinesin_motor_dom.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00225; Kinesin 
SMART
 SM00129; KISc 
PROSITE
 PS00411; KINESIN_MOTOR_DOMAIN1
 PS50067; KINESIN_MOTOR_DOMAIN2 
PRINTS
 PR00380; KINESINHEAVY.