UniProt Accession

 RRAS_HUMAN; P10301; Q6FH12 

Genbank Protein ID

 M14949; M14948; AF493920; BT006805; CR541944; CR541967; CH471177; BC016286; BC016318 

Genbank Nucleotide ID

 AAA60256.1; AAA60256.1; AAM12634.1; AAP35451.1; CAG46742.1; CAG46765.1; EAW52506.1; AAH16286.1; AAH16318.1 

Protein Name

 Ras-related protein R-Ras 

Protein Synonyms/Alias

 p23 

Gene Name

 RRAS 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
31	PPPSETHKLVVVGGG	ubiquitination	[1]
121	QSFNEVGKLFTQILR	ubiquitination	[1]
192	QLVRAVRKYQEQELP	ubiquitination	[2]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Regulates the organization of the actin cytoskeleton. 

Sequence Annotation

 NP_BIND 36 44 GTP.
 NP_BIND 83 87 GTP (By similarity).
 NP_BIND 142 145 GTP.
 NP_BIND 172 174 GTP.
 MOTIF 58 66 Effector region (By similarity).
 MOD_RES 215 215 Cysteine methyl ester (By similarity).
 LIPID 215 215 S-geranylgeranyl cysteine (By  

Keyword

 3D-structure; Cell membrane; Complete proteome; Direct protein sequencing; GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Prenylation; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 218 AA 

Protein Sequence

Gene Ontology

 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0019003; F:GDP binding; IDA:UniProtKB.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IDA:UniProtKB.
 GO:0007411; P:axon guidance; TAS:Reactome.
 GO:0030336; P:negative regulation of cell migration; IEA:Compara.
 GO:0045766; P:positive regulation of angiogenesis; IMP:UniProtKB.
 GO:0007265; P:Ras protein signal transduction; TAS:ProtInc.
 GO:0007268; P:synaptic transmission; TAS:Reactome. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR020849; Small_GTPase_Ras. 

Pfam

 PF00071; Ras 

SMART

 SM00173; RAS 

PROSITE

 PS51421; RAS 

PRINTS

 PR00449; RASTRNSFRMNG.