CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037065
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Probable E3 ubiquitin-protein ligase DTX2 
Protein Synonyms/Alias
  
Gene Name
 DTX2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
158QAFAPYNKPSLSGARacetylation[1, 2]
158QAFAPYNKPSLSGARubiquitination[2, 3, 4]
388CKTIYGEKTGTQPQGubiquitination[4]
462RKVLELLKVAWKRRLubiquitination[3, 4]
Reference
 [1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 531 AA 
Protein Sequence
MRAVRRHLFP QHSAPGRGVV WEWLSDDGSW TAYEASVCDY LEQQVARGNQ LVDLAPLGYN 60
YTVNYTTHTQ TNKTSSFCRS VRRQAGPPYP VTTIIAPPGH TGVACSCHQC LSGSRTGPVS 120
GRYRHSMTNL PAYPVPQHPP HRTASVFGTH QAFAPYNKPS LSGARSAPRL NTTNAWGAAP 180
PSLGSQPLYR SSLSHLGPQH LPPGSSTSGA VSASLPSGPS SSPGSVPATV PMQMPKPSRV 240
QQALAGMTSV LMSAIGLPVC LSRAPQPTSP PASRLASKSH GSVKRLRKMS VKGATPKPEP 300
EPEQVIKNYT EELKVPPDED CIICMEKLST ASGYSDVTDS KAIGSLAVGH LTKCSHAFHL 360
LCLLAMYCNG NKDGSLQCPS CKTIYGEKTG TQPQGKMEVL RFQMSLPGHE DCGTILIVYS 420
IPHGIQGPEH PNPGKPFTAR GFPRQCYLPD NAQGRKVLEL LKVAWKRRLI FTVGTSSTTG 480
ETDTVVWNEI HHKTEMDRNI TGHGYPDPNY LQNVLAELAA QGVTEDCLEQ Q 531 
Gene Ontology
 GO:0031965; C:nuclear membrane; IDA:HPA.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0007219; P:Notch signaling pathway; IEA:Compara. 
Interpro
 IPR004170; WWE-dom.
 IPR018123; WWE-dom_subgr.
 IPR018957; Znf_C3HC4_RING-type.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF02825; WWE
 PF00097; zf-C3HC4 
SMART
 SM00184; RING
 SM00678; WWE 
PROSITE
 PS50918; WWE
 PS50089; ZF_RING_2 
PRINTS