CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034327
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Guanine nucleotide-binding protein G(o) subunit alpha 
Protein Synonyms/Alias
  
Gene Name
 Gnao1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
15GFSGEDVKQYKPVVYubiquitination[1]
18GEDVKQYKPVVYSNTubiquitination[1]
46LGVEYGDKERKTDSKubiquitination[1]
53KERKTDSKMVCDVVSubiquitination[1]
102YQLNDSAKYYLDSLDubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; GTP-binding; Nucleotide-binding; Reference proteome; Transducer. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 179 AA 
Protein Sequence
MKIIHEDGFS GEDVKQYKPV VYSNTIQSLA AIVRAMDTLG VEYGDKERKT DSKMVCDVVS 60
RMEDTEPFSA ELLSAMMRLW GDSGIQECFN RSREYQLNDS AKYYLDSLDR IGAGDYQPTE 120
QDILRTRVKT TGIVETHFTF KNLHFRLFDV GGQRSERKKW IHCFEDVTAI IFCVALSGY 179 
Gene Ontology
 GO:0005834; C:heterotrimeric G-protein complex; IBA:RefGenome.
 GO:0043005; C:neuron projection; IEA:Compara.
 GO:0031683; F:G-protein beta/gamma-subunit complex binding; IBA:RefGenome.
 GO:0031821; F:G-protein coupled serotonin receptor binding; IBA:RefGenome.
 GO:0005525; F:GTP binding; IMP:MGI.
 GO:0003924; F:GTPase activity; IBA:RefGenome.
 GO:0004871; F:signal transducer activity; IBA:RefGenome.
 GO:0007188; P:adenylate cyclase-modulating G-protein coupled receptor signaling pathway; IBA:RefGenome.
 GO:0007568; P:aging; IEA:Compara.
 GO:0007212; P:dopamine receptor signaling pathway; IMP:MGI.
 GO:0030900; P:forebrain development; IEA:Compara.
 GO:0007626; P:locomotory behavior; IMP:MGI.
 GO:0051926; P:negative regulation of calcium ion transport; IEA:Compara.
 GO:0031175; P:neuron projection development; IEA:Compara.
 GO:0043547; P:positive regulation of GTPase activity; IEA:Compara.
 GO:0008016; P:regulation of heart contraction; IMP:MGI.
 GO:0034097; P:response to cytokine stimulus; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0042542; P:response to hydrogen peroxide; IEA:Compara.
 GO:0043278; P:response to morphine; IEA:Compara. 
Interpro
 IPR001408; Gprotein_alpha_I.
 IPR001019; Gprotein_alpha_su.
 IPR011025; GproteinA_insert.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00503; G-alpha 
SMART
 SM00275; G_alpha 
PROSITE
  
PRINTS
 PR00318; GPROTEINA.
 PR00441; GPROTEINAI.