UniProt Accession

 TRADD_HUMAN; Q15628; B2RDS3; Q52NZ1 

Genbank Protein ID

 L41690; AJ311614; AJ311615; AJ311616; AY995114; BT006934; AY575851; AK315654; CH471092; BC004491 

Genbank Nucleotide ID

 AAA98482.1; CAC38018.2; CAC38018.2; CAC38018.2; AAX89407.1; AAP35580.1; AAS68637.1; BAG38020.1; EAW83081.1; AAH04491.1 

Protein Name

 Tumor necrosis factor receptor type 1-associated DEATH domain protein 

Protein Synonyms/Alias

 TNFR1-associated DEATH domain protein; TNFRSF1A-associated via death domain 

Gene Name

 TRADD 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
163	EDALRNLKCGSGARG	ubiquitination	[1]
229	FARSVGLKWRKVGRS	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B. 

Sequence Annotation

 DOMAIN 179 289 Death.
 REGION 222 289 Interaction with KRT14 and KRT18.
 MOTIF 147 163 Nuclear export signal (By similarity).
 MOTIF 231 244 Nuclear localization signal (By  

Keyword

 3D-structure; Apoptosis; Complete proteome; Cytoplasm; Cytoskeleton; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 312 AA 

Protein Sequence

Gene Ontology

 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0043235; C:receptor complex; IDA:BHF-UCL.
 GO:0060090; F:binding, bridging; IPI:BHF-UCL.
 GO:0004871; F:signal transducer activity; IEA:InterPro.
 GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; TAS:Reactome.
 GO:0097191; P:extrinsic apoptotic signaling pathway; IMP:UniProtKB.
 GO:0006917; P:induction of apoptosis; IDA:BHF-UCL.
 GO:0051798; P:positive regulation of hair follicle development; IEA:Compara.
 GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IEP:UniProtKB.
 GO:0033209; P:tumor necrosis factor-mediated signaling pathway; TAS:BHF-UCL. 

Interpro

 IPR011029; DEATH-like_dom.
 IPR000488; Death_domain.
 IPR009095; TRADD_N. 

Pfam

 PF00531; Death
 PF09034; TRADD_N 

SMART

 SM00005; DEATH 

PROSITE

 PS50017; DEATH_DOMAIN 

PRINTS