UniProt Accession

 ARF6_MOUSE; P62331; P26438 

Genbank Protein ID

 D87903; BC003478; BC083112 

Genbank Nucleotide ID

 BAA13495.1; AAH03478.1; AAH83112.1 

Protein Name

 ADP-ribosylation factor 6 

Protein Synonyms/Alias

  

Gene Name

 Arf6 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
7	*MGKVLSKIFGNKEM	acetylation	[1]
34	TTILYKLKLGQSVTT	ubiquitination	[2]
58	TVTYKNVKFNVWDVG	acetylation	[1]
69	WDVGGQDKIRPLWRH	acetylation	[3]
69	WDVGGQDKIRPLWRH	ubiquitination	[2]
138	KPHEIQEKLGLTRIR	ubiquitination	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May modulate vesicle budding and uncoating within the Golgi apparatus Contributes to the regulation of dendritic branching and filopodia extension (By similarity). Involved in the regulation of dendritic spine development. 

Sequence Annotation

 NP_BIND 20 27 GTP (By similarity).
 NP_BIND 63 67 GTP (By similarity).
 NP_BIND 122 125 GTP (By similarity).
 LIPID 2 2 N-myristoyl glycine (By similarity).  

Keyword

 3D-structure; Cell membrane; Cell projection; Complete proteome; Differentiation; Endosome; ER-Golgi transport; Golgi apparatus; GTP-binding; Lipoprotein; Membrane; Myristate; Neurogenesis; Nucleotide-binding; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 175 AA 

Protein Sequence

Gene Ontology

 GO:0005938; C:cell cortex; IEA:Compara.
 GO:0005769; C:early endosome; IEA:Compara.
 GO:0030139; C:endocytic vesicle; ISS:UniProtKB.
 GO:0005768; C:endosome; ISS:UniProtKB.
 GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
 GO:0031527; C:filopodium membrane; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0055037; C:recycling endosome; IEA:Compara.
 GO:0001726; C:ruffle; IEA:Compara.
 GO:0005525; F:GTP binding; TAS:BHF-UCL.
 GO:0003924; F:GTPase activity; TAS:BHF-UCL.
 GO:0006915; P:apoptotic process; IMP:MGI.
 GO:0030866; P:cortical actin cytoskeleton organization; IEA:Compara.
 GO:0090162; P:establishment of epithelial cell polarity; IMP:MGI.
 GO:0001889; P:liver development; IMP:MGI.
 GO:0030838; P:positive regulation of actin filament polymerization; IEA:Compara.
 GO:0090004; P:positive regulation of establishment of protein localization to plasma membrane; IDA:BHF-UCL.
 GO:0034394; P:protein localization to cell surface; IDA:BHF-UCL.
 GO:0015031; P:protein transport; TAS:MGI.
 GO:0060998; P:regulation of dendritic spine development; IMP:UniProtKB.
 GO:0051489; P:regulation of filopodium assembly; IEA:Compara.
 GO:0035020; P:regulation of Rac protein signal transduction; IEA:Compara.
 GO:0034143; P:regulation of toll-like receptor 4 signaling pathway; NAS:BHF-UCL.
 GO:0031529; P:ruffle organization; IEA:Compara.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
 GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR024156; Small_GTPase_ARF.
 IPR006689; Small_GTPase_ARF/SAR. 

Pfam

 PF00025; Arf 

SMART

 SM00177; ARF 

PROSITE

 PS51417; ARF 

PRINTS

 PR00328; SAR1GTPBP.