UniProt Accession

 IFM3_HUMAN; Q01628; Q53Y76; Q96HK8; Q96J15 

Genbank Protein ID

 X57352; JQ610571; JQ610572; JQ610573; JQ610574; JQ610575; JQ610576; JQ610577; JQ610578; JQ610579; JQ610580; JQ610581; JQ610582; JQ610583; JQ610585; JQ610586; JQ610587; JQ610588; JQ610589; JQ610590; JQ610591; JQ610592; JQ610593; JQ610594; JQ610595; JQ610596; JQ610597; JQ610598; JQ610599; JQ610600; JQ610601; JQ610602; JQ610603; JQ610604; JQ610605; JQ610606; JQ610607; JQ610608; JQ610609; JQ610610; JQ610611; JQ610613; JQ610614; JQ610615; JQ610616; JQ610617; JQ610618; JQ610620; JQ610621; BT006892; AK292173; AC136475; CH891444; BC006794; BC008417; BC022439; BC070243 

Genbank Nucleotide ID

 CAA40626.1; AFF60305.1; AFF60306.1; AFF60307.1; AFF60308.1; AFF60309.1; AFF60310.1; AFF60311.1; AFF60312.1; AFF60313.1; AFF60314.1; AFF60315.1; AFF60316.1; AFF60317.1; AFF60319.1; AFF60320.1; AFF60321.1; AFF60322.1; AFF60323.1; AFF60324.1; AFF60325.1; AFF60326.1; AFF60327.1; AFF60328.1; AFF60329.1; AFF60330.1; AFF60331.1; AFF60332.1; AFF60333.1; AFF60334.1; AFF60335.1; AFF60336.1; AFF60337.1; AFF60338.1; AFF60339.1; AFF60340.1; AFF60341.1; AFF60342.1; AFF60343.1; AFF60344.1; AFF60345.1; AFF60347.1; AFF60348.1; AFF60349.1; AFF60350.1; AFF60351.1; AFF60352.1; AFF60354.1; AFF60355.1; AAP35538.1; BAF84862.1; EAW50866.1; AAH06794.1; AAH08417.1; AAH22439.1; AAH70243.1 

Protein Name

 Interferon-induced transmembrane protein 3 

Protein Synonyms/Alias

 Dispanin subfamily A member 2b; DSPA2b; Interferon-inducible protein 1-8U 

Gene Name

 IFITM3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
24	PPNYEMLKEEHEVAV	ubiquitination	[1]
83	IAFAYSVKSRDRKMV	ubiquitination	[1]
88	SVKSRDRKMVGDVTG	ubiquitination	[1, 2]
104	QAYASTAKCLNIWAL	ubiquitination	[1]

Reference

 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein- mediated viral entry. Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state. 

Sequence Annotation

 REGION 60 93 Interaction with SPP1.
 LIPID 71 71 S-palmitoyl cysteine.
 LIPID 72 72 S-palmitoyl cysteine.
 LIPID 105 105 S-palmitoyl cysteine.
 CROSSLNK 24 24 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 83 83 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 88 88 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 104 104 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Antiviral defense; Cell membrane; Complete proteome; Endosome; Immunity; Innate immunity; Isopeptide bond; Lipoprotein; Lysosome; Membrane; Palmitate; Polymorphism; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 133 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
 GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
 GO:0046597; P:negative regulation of viral entry into host cell; IDA:UniProtKB.
 GO:0045071; P:negative regulation of viral genome replication; IDA:UniProtKB.
 GO:0032897; P:negative regulation of viral transcription; IDA:UniProtKB.
 GO:0035455; P:response to interferon-alpha; IDA:UniProtKB.
 GO:0035456; P:response to interferon-beta; IDA:UniProtKB.
 GO:0034341; P:response to interferon-gamma; IDA:UniProtKB.
 GO:0009615; P:response to virus; IDA:UniProtKB.
 GO:0060337; P:type I interferon-mediated signaling pathway; TAS:Reactome. 

Interpro

 IPR007593; Interferon-induced_TM_protein. 

Pfam

 PF04505; CD225 

SMART

  

PROSITE

  

PRINTS