CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007701
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 LAS seventeen-binding protein 3 
Protein Synonyms/Alias
 LAS17-binding protein 3 
Gene Name
 LSB3 
Gene Synonyms/Alias
 YFR024C-A; YFR024C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
306NSGGSGGKLDDPSGAacetylation[1]
306NSGGSGGKLDDPSGAubiquitination[2]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
  
Sequence Annotation
 DOMAIN 400 459 SH3.
 MOD_RES 227 227 Phosphoserine.
 MOD_RES 298 298 Phosphothreonine.
 MOD_RES 300 300 Phosphoserine.
 MOD_RES 303 303 Phosphoserine.
 MOD_RES 393 393 Phosphothreonine.
 MOD_RES 397 397 Phosphoserine.
 MOD_RES 402 402 Phosphoserine.
 MOD_RES 416 416 Phosphoserine.  
Keyword
 3D-structure; Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome; SH3 domain. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 459 AA 
Protein Sequence
MGINNPIPRS LKSETKKAAK ILASFVKPNQ VFGADQVIPP DVLKRAKGLA IITILKAGFL 60
FSGRAGSGVI VARLKDGTWS APSAIAMAGA GAGGMVGIEL TDFVFILNTQ DAVKSFSEFG 120
TITLGGNVSV SAGPLGRSAE AAASASAGGV AAVFAYSKSK GLFAGVSVEG SAIIERREAN 180
RKFYGDNCTA KMILSGRIRP PPAVDPLFRV LESRAFNYRP SNGGRGSFDD DEDDYYDDDD 240
YYNDIPSSFS STDASSTRPN TRSTRRRAQS GSRYTFDDDD DDDDYGTGYS RNSRLAPTNS 300
GGSGGKLDDP SGASSYYASH RRSGTAQSRA RSSRNRWADD EYDDYDDDYE SGYRRGNGRD 360
RTKDREVDDL SNRFSKSRIS SASTPQTSQG RFTAPTSPST SSPKAVALYS FAGEESGDLP 420
FRKGDVITIL KKSDSQNDWW TGRVNGREGI FPANYVELV 459 
Gene Ontology
 GO:0005935; C:cellular bud neck; IDA:SGD.
 GO:0005739; C:mitochondrion; IDA:SGD.
 GO:0051666; P:actin cortical patch localization; IMP:SGD. 
Interpro
 IPR001452; SH3_domain.
 IPR007461; Ysc84_actin-binding. 
Pfam
 PF04366; DUF500
 PF00018; SH3_1 
SMART
 SM00326; SH3 
PROSITE
 PS50002; SH3 
PRINTS
 PR00452; SH3DOMAIN.