CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025686
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Triosephosphate isomerase 
Protein Synonyms/Alias
  
Gene Name
  
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
14FFVGGNWKMNGRKQSubiquitination[1]
19NWKMNGRKQSLGELIubiquitination[1]
69VAAQNCYKVTNGAFTubiquitination[1]
142REAGITEKVVFEQTKubiquitination[2, 3]
149KVVFEQTKVIADNVKubiquitination[1]
156KVIADNVKDWSKVVLubiquitination[1, 2]
160DNVKDWSKVVLAYEPubiquitination[1]
175VWAIGTGKTATPQQAubiquitination[1, 2, 3]
188QAQEVHEKLRGWLKSubiquitination[1]
194EKLRGWLKSNVSDAVubiquitination[1, 2]
238LVGGASLKPEFVDIIubiquitination[1, 2]
248FVDIINAKQ******ubiquitination[1]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931] 
Functional Description
  
Sequence Annotation
  
Keyword
 Isomerase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 249 AA 
Protein Sequence
MAPSRKFFVG GNWKMNGRKQ SLGELIGTLN AAKVPADTEV VCAPPTAYID FARQKLDPKI 60
AVAAQNCYKV TNGAFTGEIS PGMIKDCGAT WVVRGHSERR HVFGESDELI GQKVAHALAE 120
GLGVIACIGE KLDEREAGIT EKVVFEQTKV IADNVKDWSK VVLAYEPVWA IGTGKTATPQ 180
QAQEVHEKLR GWLKSNVSDA VAQSTRIIYG GSVTGATCKE LASQPDVDGF LVGGASLKPE 240
FVDIINAKQ 249 
Gene Ontology
 GO:0004807; F:triose-phosphate isomerase activity; IEA:EC.
 GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
 GO:0006096; P:glycolysis; IEA:UniProtKB-UniPathway. 
Interpro
 IPR013785; Aldolase_TIM.
 IPR022896; TrioseP_Isoase_bac/euk.
 IPR000652; Triosephosphate_isomerase.
 IPR020861; Triosephosphate_isomerase_AS. 
Pfam
 PF00121; TIM 
SMART
  
PROSITE
 PS00171; TIM_1
 PS51440; TIM_2 
PRINTS