CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004881
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Atrial natriuretic peptide receptor 2 
Protein Synonyms/Alias
 Atrial natriuretic peptide receptor type B; ANP-B; ANPR-B; NPR-B; Guanylate cyclase B; GC-B 
Gene Name
 NPR2 
Gene Synonyms/Alias
 ANPRB 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
791GFIRRFNKEGGTSILubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
 Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth. 
Sequence Annotation
 DOMAIN 513 786 Protein kinase.
 DOMAIN 861 991 Guanylate cyclase.
 MOD_RES 513 513 Phosphoserine.
 MOD_RES 516 516 Phosphothreonine.
 MOD_RES 518 518 Phosphoserine.
 MOD_RES 523 523 Phosphoserine.
 MOD_RES 526 526 Phosphoserine.
 MOD_RES 529 529 Phosphothreonine.
 CARBOHYD 24 24 N-linked (GlcNAc...) (Potential).
 CARBOHYD 35 35 N-linked (GlcNAc...) (Potential).
 CARBOHYD 161 161 N-linked (GlcNAc...) (Potential).
 CARBOHYD 195 195 N-linked (GlcNAc...) (Potential).
 CARBOHYD 244 244 N-linked (GlcNAc...) (Potential).
 CARBOHYD 277 277 N-linked (GlcNAc...) (Potential).
 CARBOHYD 349 349 N-linked (GlcNAc...) (Potential).
 DISULFID 75 101 By similarity.
 DISULFID 439 439 Interchain (Probable).
 DISULFID 448 448 Interchain (Probable).  
Keyword
 Alternative splicing; cGMP biosynthesis; Complete proteome; Disease mutation; Disulfide bond; Dwarfism; Glycoprotein; GTP-binding; Lyase; Membrane; Nucleotide-binding; Osteogenesis; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1047 AA 
Protein Sequence
MALPSLLLLV AALAGGVRPP GARNLTLAVV LPEHNLSYAW AWPRVGPAVA LAVEALGRAL 60
PVDLRFVSSE LEGACSEYLA PLSAVDLKLY HDPDLLLGPG CVYPAASVAR FASHWRLPLL 120
TAGAVASGFS AKNDHYRTLV RTGPSAPKLG EFVVTLHGHF NWTARAALLY LDARTDDRPH 180
YFTIEGVFEA LQGSNLSVQH QVYAREPGGP EQATHFIRAN GRIVYICGPL EMLHEILLQA 240
QRENLTNGDY VFFYLDVFGE SLRAGPTRAT GRPWQDNRTR EQAQALREAF QTVLVITYRE 300
PPNPEYQEFQ NRLLIRARED FGVELGPSLM NLIAGCFYDG ILLYAEVLNE TIQEGGTRED 360
GLRIVEKMQG RRYHGVTGLV VMDKNNDRET DFVLWAMGDL DSGDFQPAAH YSGAEKQIWW 420
TGRPIPWVKG APPSDNPPCA FDLDDPSCDK TPLSTLAIVA LGTGITFIMF GVSSFLIFRK 480
LMLEKELASM LWRIRWEELQ FGNSERYHKG AGSRLTLSLR GSSYGSLMTA HGKYQIFANT 540
GHFKGNVVAI KHVNKKRIEL TRQVLFELKH MRDVQFNHLT RFIGACIDPP NICIVTEYCP 600
RGSLQDILEN DSINLDWMFR YSLINDLVKG MAFLHNSIIS SHGSLKSSNC VVDSRFVLKI 660
TDYGLASFRS TAEPDDSHAL YAKKLWTAPE LLSGNPLPTT GMQKADVYSF GIILQEIALR 720
SGPFYLEGLD LSPKEIVQKV RNGQRPYFRP SIDRTQLNEE LVLLMERCWA QDPAERPDFG 780
QIKGFIRRFN KEGGTSILDN LLLRMEQYAN NLEKLVEERT QAYLEEKRKA EALLYQILPH 840
SVAEQLKRGE TVQAEAFDSV TIYFSDIVGF TALSAESTPM QVVTLLNDLY TCFDAIIDNF 900
DVYKVETIGD AYMVVSGLPG RNGQRHAPEI ARMALALLDA VSSFRIRHRP HDQLRLRIGV 960
HTGPVCAGVV GLKMPRYCLF GDTVNTASRM ESNGQALKIH VSSTTKDALD ELGCFQLELR 1020
GDVEMKGKGK MRTYWLLGER KGPPGLL 1047 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; TAS:ProtInc.
 GO:0005524; F:ATP binding; IEA:Compara.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0004383; F:guanylate cyclase activity; IDA:UniProtKB.
 GO:0042562; F:hormone binding; IPI:UniProtKB.
 GO:0016941; F:natriuretic peptide receptor activity; IDA:UniProtKB.
 GO:0017046; F:peptide hormone binding; IEA:Compara.
 GO:0004672; F:protein kinase activity; IEA:InterPro.
 GO:0004888; F:transmembrane signaling receptor activity; TAS:ProtInc.
 GO:0060348; P:bone development; IEA:Compara.
 GO:0097011; P:cellular response to granulocyte macrophage colony-stimulating factor stimulus; IEP:UniProtKB.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0001503; P:ossification; IEA:UniProtKB-KW.
 GO:0007168; P:receptor guanylyl cyclase signaling pathway; IDA:UniProtKB.
 GO:0008217; P:regulation of blood pressure; TAS:ProtInc. 
Interpro
 IPR001054; A/G_cyclase.
 IPR018297; A/G_cyclase_CS.
 IPR001828; ANF_lig-bd_rcpt.
 IPR011009; Kinase-like_dom.
 IPR001170; Ntpep_rcpt.
 IPR000719; Prot_kinase_cat_dom.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom. 
Pfam
 PF01094; ANF_receptor
 PF00211; Guanylate_cyc
 PF07714; Pkinase_Tyr 
SMART
 SM00044; CYCc 
PROSITE
 PS00458; ANF_RECEPTORS
 PS00452; GUANYLATE_CYCLASE_1
 PS50125; GUANYLATE_CYCLASE_2
 PS50011; PROTEIN_KINASE_DOM 
PRINTS
 PR00255; NATPEPTIDER.