UniProt Accession

 RCC1_HUMAN; P18754; Q16269; Q6NT97 

Genbank Protein ID

 X12654; X06130; D00591; AF498924; BC007300; BC010067; BC036903; BC069198; S75708 

Genbank Nucleotide ID

 CAA31182.1; CAA29496.1; BAA00469.1; AAM21072.1; AAH07300.1; AAH10067.1; AAH36903.1; AAH69198.1; AAB32653.1 

Protein Name

 Regulator of chromosome condensation 

Protein Synonyms/Alias

 Cell cycle regulatory protein; Chromosome condensation protein 1 

Gene Name

 RCC1 

Gene Synonyms/Alias

 CHC1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
145	GSEMVPGKVELQEKV	ubiquitination	[1]
191	IGLLEPMKKSMVPVQ	ubiquitination	[1, 2]
192	GLLEPMKKSMVPVQV	ubiquitination	[1, 3]
258	LERLLVPKCVMLKSR	ubiquitination	[1]
263	VPKCVMLKSRGSRGH	ubiquitination	[1]
366	LGEGAEEKSIPTLIS	ubiquitination	[1, 2]
393	SVGYAVTKDGRVFAW	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. Plays a key role in nucleo- cytoplasmic transport, mitosis and nuclear-envelope assembly. 

Sequence Annotation

 REPEAT 34 84 RCC1 1.
 REPEAT 85 136 RCC1 2.
 REPEAT 138 189 RCC1 3.
 REPEAT 191 257 RCC1 4.
 REPEAT 258 311 RCC1 5.
 REPEAT 312 362 RCC1 6.
 REPEAT 363 416 RCC1 7.
 MOD_RES 2 2 N,N,N-trimethylserine; alternate.
 MOD_RES 2 2 N,N-dimethylserine; alternate.
 MOD_RES 2 2 N-methylserine; alternate.
 MOD_RES 2 2 Phosphoserine.
 MOD_RES 11 11 Phosphoserine.  

Keyword

 3D-structure; Alternative splicing; Cell cycle; Cell division; Complete proteome; Cytoplasm; Direct protein sequencing; DNA-binding; Guanine-nucleotide releasing factor; Methylation; Mitosis; Nucleus; Phosphoprotein; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 421 AA 

Protein Sequence

Gene Ontology

 GO:0000794; C:condensed nuclear chromosome; IDA:UniProtKB.
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0000790; C:nuclear chromatin; IDA:UniProtKB.
 GO:0031965; C:nuclear membrane; IDA:HPA.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0042393; F:histone binding; IDA:UniProtKB.
 GO:0031492; F:nucleosomal DNA binding; IDA:UniProtKB.
 GO:0005087; F:Ran guanyl-nucleotide exchange factor activity; IDA:UniProtKB.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0007059; P:chromosome segregation; IMP:UniProtKB.
 GO:0000082; P:G1/S transition of mitotic cell cycle; IMP:UniProtKB.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0007052; P:mitotic spindle organization; IDA:UniProtKB.
 GO:0007088; P:regulation of mitosis; IDA:UniProtKB.
 GO:0051225; P:spindle assembly; IMP:UniProtKB.
 GO:0022415; P:viral reproductive process; TAS:Reactome. 

Interpro

 IPR009091; RCC1/BLIP-II.
 IPR000408; Reg_chr_condens. 

Pfam

 PF00415; RCC1 

SMART

  

PROSITE

 PS00625; RCC1_1
 PS00626; RCC1_2
 PS50012; RCC1_3 

PRINTS

 PR00633; RCCNDNSATION.