| Tag | Content |
|---|
| CPLM ID | CPLM-003307 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Coenzyme A biosynthesis bifunctional protein CoaBC |
Protein Synonyms/Alias | DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase |
Gene Name | coaBC |
Gene Synonyms/Alias | dfp; b3639; JW5642 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 215 | ISNHSSGKMGFAIAA | acetylation | [1] | | 247 | LPTPPFVKRVDVMTA | acetylation | [1] | | 292 | VAPEKIKKQATQGDE | acetylation | [1] | | 303 | QGDELTIKMVKNPDI | acetylation | [1] | | 306 | ELTIKMVKNPDIVAG | acetylation | [1] | | 385 | KVLPLERKELLGQLL | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine. |
Sequence Annotation | REGION 2 188 Phosphopantothenoylcysteine
REGION 189 406 Phosphopantothenate--cysteine ligase.
ACT_SITE 158 158 Proton donor (Probable).
BINDING 125 125 Substrate (By similarity).
BINDING 279 279 CTP.
BINDING 289 289 CTP.
BINDING 341 341 CTP.
BINDING 345 345 CTP. |
Keyword | 3D-structure; Complete proteome; Decarboxylase; Direct protein sequencing; Flavoprotein; FMN; Ligase; Lyase; Magnesium; Metal-binding; Multifunctional enzyme; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 406 AA |
Protein Sequence | MSLAGKKIVL GVSGGIAAYK TPELVRRLRD RGADVRVAMT EAAKAFITPL SLQAVSGYPV 60
SDSLLDPAAE AAMGHIELGK WADLVILAPA TADLIARVAA GMANDLVSTI CLATPAPVAV 120
LPAMNQQMYR AAATQHNLEV LASRGLLIWG PDSGSQACGD IGPGRMLDPL TIVDMAVAHF 180
SPVNDLKHLN IMITAGPTRE PLDPVRYISN HSSGKMGFAI AAAAARRGAN VTLVSGPVSL 240
PTPPFVKRVD VMTALEMEAA VNASVQQQNI FIGCAAVADY RAATVAPEKI KKQATQGDEL 300
TIKMVKNPDI VAGVAALKDH RPYVVGFAAE TNNVEEYARQ KRIRKNLDLI CANDVSQPTQ 360
GFNSDNNALH LFWQDGDKVL PLERKELLGQ LLLDEIVTRY DEKNRR 406 |
Gene Ontology | GO:0010181; F:FMN binding; IDA:EcoCyc. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0004632; F:phosphopantothenate--cysteine ligase activity; IDA:EcoCyc. GO:0004633; F:phosphopantothenoylcysteine decarboxylase activity; IDA:EcoCyc. GO:0015937; P:coenzyme A biosynthetic process; IDA:EcoCyc. GO:0015941; P:pantothenate catabolic process; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |