CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005829
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 D-dopachrome decarboxylase 
Protein Synonyms/Alias
 D-dopachrome tautomerase; Phenylpyruvate tautomerase II 
Gene Name
 DDT 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
21RVPAGLEKRLCAAAAubiquitination[1, 2, 3]
87HFFEFLTKELALGQDubiquitination[4]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
 Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI). 
Sequence Annotation
 MOD_RES 2 2 N-acetylproline (By similarity).  
Keyword
 3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Lyase; Melanin biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 118 AA 
Protein Sequence
MPFLELDTNL PANRVPAGLE KRLCAAAASI LGKPADRVNV TVRPGLAMAL SGSTEPCAQL 60
SISSIGVVGT AEDNRSHSAH FFEFLTKELA LGQDRILIRF FPLESWQIGK IGTVMTFL 118 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0033981; F:D-dopachrome decarboxylase activity; IEA:EC.
 GO:0004167; F:dopachrome isomerase activity; TAS:ProtInc.
 GO:0042438; P:melanin biosynthetic process; IEA:UniProtKB-KW. 
Interpro
 IPR001398; Macrophage_inhib_fac.
 IPR019829; Macrophage_inhib_fac_CS.
 IPR014347; Tautomerase/MIF_sf. 
Pfam
 PF01187; MIF 
SMART
  
PROSITE
 PS01158; MIF 
PRINTS