| Tag | Content |
|---|
| CPLM ID | CPLM-016175 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | TBC1 domain family member 1 |
Protein Synonyms/Alias | |
Gene Name | TBC1D1 |
Gene Synonyms/Alias | KIAA1108 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 248 | LRSLAFRKELQDGGL | ubiquitination | [1] | | 1092 | KTNSSLRKQNLDLLE | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity). |
Sequence Annotation | DOMAIN 246 404 PID.
DOMAIN 800 994 Rab-GAP TBC.
MOD_RES 146 146 Phosphoserine (By similarity).
MOD_RES 235 235 Phosphoserine; by PKB/AKT1 (By
MOD_RES 237 237 Phosphoserine; by AMPK (By similarity).
MOD_RES 503 503 Phosphoserine (By similarity).
MOD_RES 505 505 Phosphothreonine; by PKB/AKT1 (By
MOD_RES 507 507 Phosphoserine.
MOD_RES 525 525 Phosphoserine (By similarity).
MOD_RES 527 527 Phosphoserine (By similarity).
MOD_RES 565 565 Phosphoserine.
MOD_RES 570 570 Phosphoserine.
MOD_RES 571 571 Phosphoserine (By similarity).
MOD_RES 573 573 Phosphoserine.
MOD_RES 585 585 Phosphoserine.
MOD_RES 596 596 Phosphothreonine (By similarity).
MOD_RES 614 614 Phosphoserine (By similarity).
MOD_RES 627 627 Phosphoserine; by PKB/AKT1 (By
MOD_RES 941 941 Phosphoserine (By similarity).
MOD_RES 952 952 Phosphotyrosine (By similarity).
MOD_RES 1131 1131 Phosphothreonine (By similarity). |
Keyword | 3D-structure; Alternative splicing; Complete proteome; GTPase activation; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1168 AA |
Protein Sequence | MEPITFTARK HLLSNEVSVD FGLQLVGSLP VHSLTTMPML PWVVAEVRRL SRQSTRKEPV 60
TKQVRLCVSP SGLRCEPEPG RSQQWDPLIY SSIFECKPQR VHKLIHNSHD PSYFACLIKE 120
DAVHRQSICY VFKADDQTKV PEIISSIRQA GKIARQEELH CPSEFDDTFS KKFEVLFCGR 180
VTVAHKKAPP ALIDECIEKF NHVSGSRGSE SPRPNPPHAA PTGSQEPVRR PMRKSFSQPG 240
LRSLAFRKEL QDGGLRSSGF FSSFEESDIE NHLISGHNIV QPTDIEENRT MLFTIGQSEV 300
YLISPDTKKI ALEKNFKEIS FCSQGIRHVD HFGFICRESS GGGGFHFVCY VFQCTNEALV 360
DEIMMTLKQA FTVAAVQQTA KAPAQLCEGC PLQSLHKLCE RIEGMNSSKT KLELQKHLTT 420
LTNQEQATIF EEVQKLRPRN EQRENELIIS FLRCLYEEKQ KEHIHIGEMK QTSQMAAENI 480
GSELPPSATR FRLDMLKNKA KRSLTESLES ILSRGNKARG LQEHSISVDL DSSLSSTLSN 540
TSKEPSVCEK EALPISESSF KLLGSSEDLS SDSESHLPEE PAPLSPQQAF RRRANTLSHF 600
PIECQEPPQP ARGSPGVSQR KLMRYHSVST ETPHERKDFE SKANHLGDSG GTPVKTRRHS 660
WRQQIFLRVA TPQKACDSSS RYEDYSELGE LPPRSPLEPV CEDGPFGPPP EEKKRTSREL 720
RELWQKAILQ QILLLRMEKE NQKLQASEND LLNKRLKLDY EEITPCLKEV TTVWEKMLST 780
PGRSKIKFDM EKMHSAVGQG VPRHHRGEIW KFLAEQFHLK HQFPSKQQPK DVPYKELLKQ 840
LTSQQHAILI DLGRTFPTHP YFSAQLGAGQ LSLYNILKAY SLLDQEVGYC QGLSFVAGIL 900
LLHMSEEEAF KMLKFLMFDM GLRKQYRPDM IILQIQMYQL SRLLHDYHRD LYNHLEEHEI 960
GPSLYAAPWF LTMFASQFPL GFVARVFDMI FLQGTEVIFK VALSLLGSHK PLILQHENLE 1020
TIVDFIKSTL PNLGLVQMEK TINQVFEMDI AKQLQAYEVE YHVLQEELID SSPLSDNQRM 1080
DKLEKTNSSL RKQNLDLLEQ LQVANGRIQS LEATIEKLLS SESKLKQAML TLELERSALL 1140
QTVEELRRRS AEPSDREPEC TQPEPTGD 1168 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0005097; F:Rab GTPase activator activity; IEA:InterPro. GO:0016044; P:cellular membrane organization; TAS:Reactome. GO:0032851; P:positive regulation of Rab GTPase activity; IEA:GOC. GO:0032880; P:regulation of protein localization; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |