| Tag | Content |
|---|
| CPLM ID | CPLM-012932 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein inscuteable homolog |
Protein Synonyms/Alias | Minsc |
Gene Name | Insc |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 189 | AEKLLMEKCSELSAV | ubiquitination | [1] | | 489 | ACERVQQKAAVTLAR | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex. Involved in spindle orientation during mitosis it may regulate cell proliferation and differentiation in the developing nervous system. May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium. |
Sequence Annotation | MOTIF 576 579 PDZ-binding. |
Keyword | 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Developmental protein; Differentiation; Neurogenesis; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 579 AA |
Protein Sequence | MRRPPGDGDS TGEGPGNWGL WGAQESRRLC CVGPDRCGQA LLQIGINMMA LPGGRHLDSV 60
PLQEQRLHFM QVDSVQRWME DLKLMTECEC MCVLQAKPIS LEEDTQGDLI LAGGPGPGDP 120
LQLLLKRGWV ISTELRRIGQ KLAQDRWARV HSMSVRLTCH ARSMVSEYST ISRTASQEMG 180
QAEKLLMEKC SELSAVTERC LQVENEHVLK SMKACVSETL SLLGEHFGQL LELALTREVQ 240
ALVRKIDTSD NIYITESTTG NLFGLTQEGA PLCRIIAKEG GVVALFKVCR QDSFRCLYPQ 300
ALRTLASICC VEEGVHQLEK VDGILCLADI LTDESHSEAT RAEAAAVVAQ VTSPHLSFTQ 360
HLTSFLENME EIVTALIKLC QEASSGEVFL LASAALANIT FFDKMACEML LQLNAIRVLL 420
EACGDKQRVD TPYTRDQIVT ILANMSVLEQ CGSDIIQENG VQLIMGMLSE KPRSGTPAEV 480
AACERVQQKA AVTLARLCRD PDVAQEAVRL SCMSRLIELC RSPSERNSSD AVLVACLAAL 540
RRLAGVCPEG LQDSDFQQLV QPRLVDSFLL CSNMEESFV 579 |
Gene Ontology | GO:0045177; C:apical part of cell; IDA:MGI. GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0000132; P:establishment of mitotic spindle orientation; IMP:MGI. GO:0060487; P:lung epithelial cell differentiation; IMP:MGI. GO:0007399; P:nervous system development; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |