CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043399
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Gamma-tubulin complex component 4 
Protein Synonyms/Alias
  
Gene Name
 TUBGCP4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
152GIGGLTGKQLRELQDubiquitination[1, 2, 3, 4]
174NMLAPSLKQFSLRVEubiquitination[2, 3]
220TRKGSILKNQEDTFAubiquitination[3]
234AAELHRLKQQPLFSLubiquitination[1, 2, 3, 4]
277LGQLKIIKDFYLLGRubiquitination[5]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 397 AA 
Protein Sequence
XGIYLRAFCT GLDSVLQPYR QALLDLEQEF LGDPHLSISH VNYFLDQFQL LFPSVMVVVE 60
QIKSQKIHGC QILETVYKHS CGGLPPVRSA LEKILAVCHG VMYKQLSAWM LHGLLLDQHE 120
EFFIKQGPSS GNVSAQPEED EEDLGIGGLT GKQLRELQDL RLIEEENMLA PSLKQFSLRV 180
EILPSYIPVR VAEKILFVGE SVQMFENQNV NLTRKGSILK NQEDTFAAEL HRLKQQPLFS 240
LVDFEQVVDR IRSTVAEHLW KLMVEESDLL GQLKIIKDFY LLGRGELFQA FIDTAQHMLK 300
TPPTAVTEHD VNVAFQQSAH KVLLDDDNLL PLLHLTIEYH GKEHKADATQ AREGPSRETS 360
PREAPASGWA ALGLSYKVQW PLHILFTPAV LEKNRQF 397 
Gene Ontology
 GO:0005815; C:microtubule organizing center; IEA:InterPro.
 GO:0000922; C:spindle pole; IEA:InterPro.
 GO:0000226; P:microtubule cytoskeleton organization; IEA:InterPro. 
Interpro
 IPR007259; Spc97_Spc98. 
Pfam
 PF04130; Spc97_Spc98 
SMART
  
PROSITE
  
PRINTS