CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041583
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Double-strand break repair protein MRE11A 
Protein Synonyms/Alias
 Meiotic recombination 11 homolog A (S. cerevisiae), isoform CRA_a 
Gene Name
 Mre11a 
Gene Synonyms/Alias
 rCG_31743 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
671WSGTAPSKRMSQSQTacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; DNA damage; DNA repair; Endonuclease; Exonuclease; Hydrolase; Manganese; Meiosis; Nuclease; Nucleus; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 706 AA 
Protein Sequence
MSPADPLDDE DTFKILVATD IHLGFMEKDA VRGNDTFVTF DEILRLALEN EVDFILLGGD 60
LFHENKPSRK TLHSCLELLR KYCMGDRPVQ FEIISDQSVN FGFSKFPWVN YQDGNLNISI 120
PVFSIHGNHD DPTGADALCA LDVLSCAGFV NHFGRSMSVE KVDISPVLLQ KGSTKLALYG 180
LGSIPDERLY RMFVNKKVTM LRPKEDENSW FNLFVIHQNR SKHGSTNFIP EQFLDDFIDL 240
VIWGHEHECK IGPTRNEQQL FYVSQPGSSV VTALSPGETV KKHVGLLRVK GRKMNMQKLP 300
LRTVRQFFME DVVLANHPSL FNPDNPKVTQ AIQSFCLEKI EEMLDSAERE RLGNPQQPEK 360
PLIRLRVDYS GGFEPFNVLR FSQKFVDRVA NPKDVIHFFR HREQKGKTGE EINFGKLIIK 420
PASEGTTLRV EDLVKQYFQT AEKNVQLSLL TERGMGEAVQ EFVDKEEKDA IEELVKYQLE 480
KTQRFLKERH IDALEDKIDE EVRRFRESRQ RNTNEEDDEV REAMSRARAL RSQSENAASA 540
FSADDLSFDI TEQTADDSDD SQSAVPSRGR GRGRGRRGGR GQSTAPRGGS QRGRDTGLGI 600
STRGRSSKAT ASTSRNMSII DAFRSTRQQP SRNVATKNYS ETIEVDESDD DDSFPTSSRA 660
DQRWSGTAPS KRMSQSQTAK GVDFESDEDD DDDPFMSGSC PRRNRR 706 
Gene Ontology
 GO:0000781; C:chromosome, telomeric region; IEA:Compara.
 GO:0005634; C:nucleus; IEA:UniProtKB-KW.
 GO:0004003; F:ATP-dependent DNA helicase activity; IEA:Compara.
 GO:0003677; F:DNA binding; IEA:Compara.
 GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
 GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
 GO:0030145; F:manganese ion binding; IEA:InterPro.
 GO:0000075; P:cell cycle checkpoint; IEA:Compara.
 GO:0008283; P:cell proliferation; IEA:Compara.
 GO:0006302; P:double-strand break repair; IEA:Compara.
 GO:0032876; P:negative regulation of DNA endoreduplication; IEA:Compara.
 GO:0090305; P:nucleic acid phosphodiester bond hydrolysis; IEA:GOC.
 GO:0033674; P:positive regulation of kinase activity; IEA:Compara.
 GO:0031954; P:positive regulation of protein autophosphorylation; IEA:Compara.
 GO:0007062; P:sister chromatid cohesion; IEA:Compara.
 GO:0007129; P:synapsis; IEA:Compara. 
Interpro
 IPR003701; DNA_repair_Mre11.
 IPR004843; Metallo_PEstase_dom.
 IPR007281; Mre11_DNA-bd. 
Pfam
 PF00149; Metallophos
 PF04152; Mre11_DNA_bind 
SMART
  
PROSITE
  
PRINTS