CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038949
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Rap guanine nucleotide exchange factor 4 
Protein Synonyms/Alias
  
Gene Name
 Rapgef4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
553TWEKLPSKFKKFYAEacetylation[1]
580AYRLTAAKLEPPLIPacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Guanine-nucleotide releasing factor; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 676 AA 
Protein Sequence
PGQRTADDLE IIYDELLHIK ALSHLSTTVK RELAGVLIFE SHAKGGTVLF NQGEEGTSWY 60
IILKGSVNVV IYGKGVVCTL HEGDDFGKLA LVNDAPRAAS IVLREDNCHF LRVDKEDFNR 120
ILRDVEANTV RLKEHDQDVL VLEKVPAGNR ASNQGNSQPQ QKYTVMSGTP EKILEHFLET 180
IRLEPSLNEA TDSVLNDFVM MHCVFMPNTQ LCPALVAHYH AQPSQGTEQE RMDYALNNKR 240
RVIRLVLQWA AMYGDLLQED DVAMAFLEEF YVSVSDDARM MVAFKEQLAE LEKTVKQISE 300
DAKAPQKKHK VLLQQFNTGD ERAQKRQPIR GSDEVLFKVY CIDHTYTTIR VPVAASVKEV 360
ISAVADKLGS GEGLIIVKMN SGGEKVVLKP NDVSVFTTLT INGRLFACPR EQFDSLTPLP 420
EQEGPTTGTV GTFELMSSKD LAYQMTTYDW ELFNCVHELE LIYHTFGRHN FKKTTANLDL 480
FLRRFNEIQF WVVTEICLCS QLSKRVQLLK KFIKIAAHCK EYKNLNSFFA IVMGLSNVAV 540
SRLALTWEKL PSKFKKFYAE FESLMDPSRN HRAYRLTAAK LEPPLIPFMP LLIKDMTFTH 600
EGNKTFIDNL VNFEKMRMIA NTARTVRYYR SQPFNPDAAQ ANKNHQDVRS YVRQLNVIDN 660
QRTLSQMSHR LEPRRP 676 
Gene Ontology
 GO:0005952; C:cAMP-dependent protein kinase complex; IEA:InterPro.
 GO:0008603; F:cAMP-dependent protein kinase regulator activity; IEA:InterPro.
 GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
 GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 
Interpro
 IPR002373; cAMP/cGMP_kin.
 IPR018490; cNMP-bd-like.
 IPR000595; cNMP-bd_dom.
 IPR000159; Ras-assoc.
 IPR000651; Ras-like_Gua-exchang_fac_N.
 IPR019804; Ras_G-nucl-exch_fac_CS.
 IPR008937; Ras_GEF.
 IPR023578; Ras_GEF_dom.
 IPR001895; RasGRF_CDC25.
 IPR014710; RmlC-like_jellyroll. 
Pfam
 PF00027; cNMP_binding
 PF00788; RA
 PF00617; RasGEF
 PF00618; RasGEF_N 
SMART
 SM00100; cNMP
 SM00147; RasGEF
 SM00229; RasGEFN 
PROSITE
 PS50042; CNMP_BINDING_3
 PS00720; RASGEF
 PS50009; RASGEF_CAT
 PS50212; RASGEF_NTER 
PRINTS
 PR00103; CAMPKINASE.