| Tag | Content |
|---|
| CPLM ID | CPLM-011762 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ribosome biogenesis protein NOP53 |
Protein Synonyms/Alias | Nucleolar protein 53 |
Gene Name | NOP53 |
Gene Synonyms/Alias | YPL146C; LPI2C; P2610 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 26 | KGKKAWRKNIDLSDV | acetylation | [1] | | 121 | NKIQGVSKHELKKLM | acetylation | [1] | | 225 | TEIPHAGKSYNPNNK | acetylation | [1] | | 386 | KKHKLGTKYSVIDER | acetylation | [1] | | 448 | YKQKITEKWTHKDFK | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Late-acting factor in the nuclear maturation of 60S ribosomal subunits, which is required for normal acquisition of export competence. Required for the export of the large subunit. Acts to stimulate the RNase activity of the exosome complex, and may recruit the exosome to 7S pre-rRNA for processing. Associates with numerous RNAs including the 27S and 7S pre-rRNAs and the box H/ACA snoRNA snR37. Also interacts (via N-terminal region) with the mature 25S rRNA and the mature 5.8S rRNA. |
Sequence Annotation | MOD_RES 31 31 Phosphoserine. |
Keyword | Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Ribosome biogenesis; RNA-binding; rRNA processing. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 455 AA |
Protein Sequence | MAPTNLTKKP SQYKQSSRKG KKAWRKNIDL SDVEQYMEKK IDHEITHGTS DITSLQNDAL 60
FHVDVEGDEI LKNKLIKRKQ IKKVLKSKEI LDAVKTNSKI AALNHHKNSS GNPNKIQGVS 120
KHELKKLMAL AGRVHGESKI KNRVAKDGLV KTTAGDLWGE ESNSKKQKVK LPSGIKLDVE 180
KKDQIPEELL KKSTTSWSTA SVRPSTLDIE PIAVKEFTEI PHAGKSYNPN NKAWSELINK 240
EYKEEKARED ERIALEKYKE RIRHLMETLD DNEEEESSSN EEEEEEEEEN ENENESTQCS 300
GSDKEIKLSI NKPVKNKKKT KYQRNKAKRH EEKVKLQQEL KELRQRVKDL EEVINSEETE 360
ILSAIESDSN KVKKSKKNKK HKLGTKYSVI DERLEIKFSD ELSDSLRKLK PEGNLLYDTV 420
RKLQSSGKVE TRVPVRKGRK YKQKITEKWT HKDFK 455 |
Gene Ontology | GO:0005730; C:nucleolus; IDA:SGD. GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell. GO:0019843; F:rRNA binding; IDA:SGD. GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD. GO:0000055; P:ribosomal large subunit export from nucleus; IMP:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |