CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031682
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Pescadillo homolog 
Protein Synonyms/Alias
  
Gene Name
 PES1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
26TRNKARKKLQLSLADubiquitination[1]
41FRRLCILKGIYPHEPubiquitination[1, 2, 3]
68ARTFYLIKDIRFLLHubiquitination[1, 2, 4]
81LHEPIVNKFREYKVFubiquitination[1, 2, 3, 4, 5, 6]
86VNKFREYKVFVRKLRubiquitination[1, 3]
94VFVRKLRKAYGKSEWubiquitination[1]
98KLRKAYGKSEWNTVEacetylation[7, 8]
98KLRKAYGKSEWNTVEubiquitination[1, 3, 5]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [6] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [7] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [8] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Nucleus; Reference proteome; Ribosome biogenesis; rRNA processing. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 571 AA 
Protein Sequence
MGGLEKKKYE RGSATNYITR NKARKKLQLS LADFRRLCIL KGIYPHEPKH KKKVNKGSTA 60
ARTFYLIKDI RFLLHEPIVN KFREYKVFVR KLRKAYGKSE WNTVERLKDN KPNYKLDHII 120
KERYPTFIDA LRDLDDALSM CFLFSTFPRT GKCHVQTIQL CRRLTVEFMH YIIAARALRK 180
VFLSIKGIYY QAEHPTDVDY RVMATFTEFY TTLLGFVNFR LYQLLNLHYP PKLEGQAQAE 240
AKAGEGTYAL DSESCMEKLA ALSASLARVV VPATEEEAEV DEFPTDGEMS AQEEDRRKEL 300
EAQEKHKKLF EGLKFFLNRE VPREALAFII RSFGGEVSWD KSLCIGATYD VTDSRITHQI 360
VDRPGQQTSV IGRCYVQPQW VFDSVNARLL LPVAEYFSGV QLPPHLSPFV TEKEGDYVPP 420
EKLKLLALQR GEDPGNLNES EEEEEEDDNN EGDGDEEGEN EEEEEDAEAG SEKEEEARLA 480
ALEEQRMEGK KPRVMAGTLK LEDKQRLAQE EESEAKRLAI MMMKKREKYL YQKIMFGKRR 540
KIREANKLAE KRKAHDEAVR SEKKAKKARP E 571 
Gene Ontology
 GO:0005730; C:nucleolus; IEA:InterPro.
 GO:0006364; P:rRNA processing; IEA:UniProtKB-KW. 
Interpro
 IPR001357; BRCT_dom.
 IPR010613; Pescadillo. 
Pfam
 PF00533; BRCT
 PF06732; Pescadillo_N 
SMART
 SM00292; BRCT 
PROSITE
 PS50172; BRCT 
PRINTS