UniProt Accession

 F1LQC7_RAT; F1LQC7 

Genbank Protein ID

 AABR06028748 

Genbank Nucleotide ID

  

Protein Name

 Nitric oxide synthase 

Protein Synonyms/Alias

  

Gene Name

 Nos3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
1084	SRDPGSPKTYVQDLL	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Produces nitric oxide (NO) (By similarity). 

Sequence Annotation

  

Keyword

 Calmodulin-binding; Complete proteome; FAD; FMN; Heme; Iron; Metal-binding; NADP; Oxidoreductase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1202 AA 

Protein Sequence

Gene Ontology

 GO:0005901; C:caveola; IEA:Compara.
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0034618; F:arginine binding; IEA:Compara.
 GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
 GO:0010181; F:FMN binding; IEA:InterPro.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0050661; F:NADP binding; IEA:InterPro.
 GO:0004517; F:nitric-oxide synthase activity; IEA:EC.
 GO:0034617; F:tetrahydrobiopterin binding; IEA:Compara.
 GO:0001525; P:angiogenesis; IEA:Compara.
 GO:0006527; P:arginine catabolic process; IEA:Compara.
 GO:0001974; P:blood vessel remodeling; IEA:Compara.
 GO:0043542; P:endothelial cell migration; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Compara.
 GO:0030324; P:lung development; IEA:Compara.
 GO:0051926; P:negative regulation of calcium ion transport; IEA:Compara.
 GO:0008285; P:negative regulation of cell proliferation; IEA:Compara.
 GO:0051346; P:negative regulation of hydrolase activity; IEA:Compara.
 GO:0014740; P:negative regulation of muscle hyperplasia; IEA:Compara.
 GO:0043267; P:negative regulation of potassium ion transport; IEA:Compara.
 GO:0006809; P:nitric oxide biosynthetic process; IEA:Compara.
 GO:0001542; P:ovulation from ovarian follicle; IEA:Compara.
 GO:0045766; P:positive regulation of angiogenesis; IEA:Compara.
 GO:0050880; P:regulation of blood vessel size; IEA:Compara.
 GO:0002028; P:regulation of sodium ion transport; IEA:Compara.
 GO:0003100; P:regulation of systemic arterial blood pressure by endothelin; IEA:Compara.
 GO:0003057; P:regulation of the force of heart contraction by chemical signal; IEA:Compara.
 GO:0034405; P:response to fluid shear stress; IEA:Compara.
 GO:0014806; P:smooth muscle hyperplasia; IEA:Compara. 

Interpro

 IPR003097; FAD-binding_1.
 IPR017927; Fd_Rdtase_FAD-bd.
 IPR001094; Flavdoxin.
 IPR008254; Flavodoxin/NO_synth.
 IPR001709; Flavoprot_Pyr_Nucl_cyt_Rdtase.
 IPR023173; NADPH_Cyt_P450_Rdtase_dom3.
 IPR004030; NO_synthase_oxygenase_dom.
 IPR026009; NOS.
 IPR012144; NOS_met.
 IPR001433; OxRdtase_FAD/NAD-bd.
 IPR017938; Riboflavin_synthase-like_b-brl. 

Pfam

 PF00667; FAD_binding_1
 PF00258; Flavodoxin_1
 PF00175; NAD_binding_1
 PF02898; NO_synthase 

SMART

  

PROSITE

 PS51384; FAD_FR
 PS50902; FLAVODOXIN_LIKE
 PS60001; NOS 

PRINTS

 PR00369; FLAVODOXIN.
 PR00371; FPNCR.