UniProt Accession

 BRAF_MOUSE; P28028; E9QNG9; Q3USE9 

Genbank Protein ID

 AK140431; AC122345; AC163109; M64429 

Genbank Nucleotide ID

 BAE24384.1; AAA37320.1 

Protein Name

 Serine/threonine-protein kinase B-raf 

Protein Synonyms/Alias

 Proto-oncogene B-Raf 

Gene Name

 Braf 

Gene Synonyms/Alias

 B-raf 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
148	VRVFLPNKQRTVVPA	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron (By similarity). 

Sequence Annotation

 DOMAIN 139 211 RBD.
 DOMAIN 494 754 Protein kinase.
 NP_BIND 500 508 ATP (By similarity).
 ACT_SITE 613 613 Proton acceptor (By similarity).
 METAL 219 219 Zinc 1 (By similarity).
 METAL 232 232 Zinc 2 (By similarity).
 METAL 235 235 Zinc 2 (By similarity).
 METAL 245 245 Zinc 1 (By similarity).
 METAL 248 248 Zinc 1 (By similarity).
 METAL 253 253 Zinc 2 (By similarity).
 METAL 256 256 Zinc 2 (By similarity).
 METAL 264 264 Zinc 1 (By similarity).
 BINDING 520 520 ATP (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 348 348 Phosphoserine; by SGK1 (By similarity).
 MOD_RES 356 356 Phosphothreonine; by autocatalysis (By
 MOD_RES 431 431 Phosphothreonine (By similarity).
 MOD_RES 434 434 Phosphoserine (By similarity).
 MOD_RES 436 436 Phosphothreonine (By similarity).
 MOD_RES 483 483 Phosphoserine.
 MOD_RES 484 484 Phosphoserine (By similarity).
 MOD_RES 708 708 Omega-N-methylarginine; by PRMT5 (By
 MOD_RES 766 766 Phosphoserine (By similarity).
 MOD_RES 790 790 Phosphothreonine; by MAPK1 (By  

Keyword

 Acetylation; Alternative splicing; ATP-binding; Cell membrane; Chromosomal rearrangement; Complete proteome; Cytoplasm; Kinase; Membrane; Metal-binding; Methylation; Nucleotide-binding; Nucleus; Phosphoprotein; Proto-oncogene; Reference proteome; Serine/threonine-protein kinase; Transferase; Ubl conjugation; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 804 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0005509; F:calcium ion binding; IEA:Compara.
 GO:0004672; F:protein kinase activity; IDA:BHF-UCL.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
 GO:0005057; F:receptor signaling protein activity; IEA:InterPro.
 GO:0071277; P:cellular response to calcium ion; IEA:Compara.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Compara.
 GO:0010628; P:positive regulation of gene expression; IEA:Compara.
 GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Compara.
 GO:0070849; P:response to epidermal growth factor stimulus; IDA:BHF-UCL. 

Interpro

 IPR020454; DAG/PE-bd.
 IPR011009; Kinase-like_dom.
 IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR003116; Raf-like_ras-bd.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
 IPR008271; Ser/Thr_kinase_AS. 

Pfam

 PF00130; C1_1
 PF07714; Pkinase_Tyr
 PF02196; RBD 

SMART

 SM00109; C1
 SM00455; RBD 

PROSITE

 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST
 PS50898; RBD
 PS00479; ZF_DAG_PE_1
 PS50081; ZF_DAG_PE_2 

PRINTS

 PR00008; DAGPEDOMAIN.