| Tag | Content |
|---|
| CPLM ID | CPLM-008763 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Phosphatidylinositol transfer protein PDR17 |
Protein Synonyms/Alias | PITP; Phosphatidylserine transport B pathway protein 2; Pleiotropic drug resistance protein 17; SEC14 homolog 3 |
Gene Name | PDR17 |
Gene Synonyms/Alias | ISS1; PSTB2; SFH4; YNL264C; N0815 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 49 | ISEDQNEKYRAVLRH | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Has phosphatidylinositol transfer activity. Involved in the regulation of the phospholipid composition of plasma- and endomembranes. Altering plasma membrane composition may provide a possible mechanism for multidrug resistance. Contributes to efficient phospholipase D1 activation and phospholipase B1 inhibition in the regulation of phospholipid turnover. |
Sequence Annotation | DOMAIN 139 297 CRAL-TRIO. |
Keyword | Complete proteome; Cytoplasm; Lipid transport; Reference proteome; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 350 AA |
Protein Sequence | MGLFSRKRDH TPAVPKEKLI PCDKIFLDPP AKYGNAPLLE PISEDQNEKY RAVLRHFQDD 60
DLKLPENLND LDNGTHANDR PLSDWEKFWL SRECFLRYLR ANKWNTANAI KGLTKTLVWR 120
REIGLTHGKE DKDPLTADKV AVENETGKQV ILGFDNAKRP LYYMKNGRQN TESSFRQVQE 180
LVYMMETATT VAPQGVEKIT VLVDFKSYKE PGIITDKAPP ISIARMCLNV MQDHYPERLA 240
KCVLINIPWF AWAFLKMMYP FLDPATKAKA IFDEPFENHI EPSQLDALYN GLLDFKYKHE 300
VYWPDMVKKV DDLRLKRFDR FLKFGGIVGL SEYDTKGQHD ELKYPVDMVI 350 |
Gene Ontology | GO:0071944; C:cell periphery; IDA:SGD. GO:0005829; C:cytosol; IDA:SGD. GO:0005768; C:endosome; IDA:SGD. GO:0008526; F:phosphatidylinositol transporter activity; IDA:SGD. GO:0043001; P:Golgi to plasma membrane protein transport; IGI:SGD. GO:1901352; P:negative regulation of phosphatidylglycerol biosynthetic process; IGI:SGD. GO:0006658; P:phosphatidylserine metabolic process; IMP:SGD. GO:0008654; P:phospholipid biosynthetic process; IGI:SGD. GO:2001247; P:positive regulation of phosphatidylcholine biosynthetic process; IGI:SGD. GO:0042493; P:response to drug; IGI:SGD. GO:0016126; P:sterol biosynthetic process; IGI:SGD. |
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