UniProt Accession

 ICAM2_HUMAN; P13598; Q14600 

Genbank Protein ID

 X15606; M32334; M32331; M32332; M32333; BC003097 

Genbank Nucleotide ID

 CAA33630.1; AAA36035.1; AAA36035.1; AAA36035.1; AAA36035.1; AAH03097.1 

Protein Name

 Intercellular adhesion molecule 2 

Protein Synonyms/Alias

 ICAM-2; CD102 

Gene Name

 ICAM2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
163	LHYETFGKAAPAPQE	ubiquitination	[1]
206	RGGNIFHKHSAPKML	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen- specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. 

Sequence Annotation

 DOMAIN 41 98 Ig-like C2-type 1.
 DOMAIN 127 197 Ig-like C2-type 2.
 CARBOHYD 47 47 N-linked (GlcNAc...).
 CARBOHYD 82 82 N-linked (GlcNAc...).
 CARBOHYD 105 105 N-linked (GlcNAc...).
 CARBOHYD 153 153 N-linked (GlcNAc...).
 CARBOHYD 176 176 N-linked (GlcNAc...).
 CARBOHYD 187 187 N-linked (GlcNAc...).
 DISULFID 48 91
 DISULFID 52 95
 DISULFID 134 190  

Keyword

 3D-structure; Cell adhesion; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 275 AA 

Protein Sequence

Gene Ontology

 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0001931; C:uropod; IEA:Compara.
 GO:0005178; F:integrin binding; TAS:ProtInc.
 GO:0016337; P:cell-cell adhesion; IEA:InterPro.
 GO:0050776; P:regulation of immune response; TAS:Reactome. 

Interpro

 IPR003988; ICAM.
 IPR015653; ICAM2.
 IPR013768; ICAM_N.
 IPR003987; ICAM_VCAM_N.
 IPR013783; Ig-like_fold. 

Pfam

 PF03921; ICAM_N 

SMART

  

PROSITE

 PS50835; IG_LIKE 

PRINTS

 PR01473; ICAM.
 PR01472; ICAMVCAM1.