CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024603
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Carbonic anhydrase 1 
Protein Synonyms/Alias
 Carbonate dehydratase I; Carbonic anhydrase I; CA-I 
Gene Name
 Ca1 
Gene Synonyms/Alias
 Car1 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
40DIKTSEAKHDSSLKPacetylation[1]
46AKHDSSLKPVSVSYNacetylation[1]
128LVHWNSAKYSSAAEAacetylation[1]
160PANPNLQKVLDALSSacetylation[1]
253HRPPQPLKGRTVRASacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Reversible hydration of carbon dioxide. 
Sequence Annotation
 REGION 200 201 Substrate binding (By similarity).
 ACT_SITE 65 65 Proton acceptor (By similarity).
 ACT_SITE 129 129 By similarity.
 METAL 95 95 Zinc; catalytic (By similarity).
 METAL 97 97 Zinc; catalytic (By similarity).
 METAL 120 120 Zinc; catalytic (By similarity).
 BINDING 200 200 Substrate (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).  
Keyword
 Acetylation; Complete proteome; Cytoplasm; Lyase; Metal-binding; Reference proteome; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 261 AA 
Protein Sequence
MASADWGYDS KNGPDQWSKL YPIANGNNQS PIDIKTSEAK HDSSLKPVSV SYNPATAKEI 60
VNVGHSFHVV FDDSSNQSVL KGGPLADSYR LTQFHFHWGN SNDHGSEHTV DGAKYSGELH 120
LVHWNSAKYS SAAEAISKAD GLAIIGVLMK VGPANPNLQK VLDALSSVKT KGKRAPFTNF 180
DPSSLLPSSL DYWTYFGSLT HPPLHESVTW VICKESISLS PEQLAQLRGL LSSAEGEPAV 240
PVLSNHRPPQ PLKGRTVRAS F 261 
Gene Ontology
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0004089; F:carbonate dehydratase activity; IEA:EC.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006730; P:one-carbon metabolic process; IEA:InterPro. 
Interpro
 IPR001148; Carbonic_anhydrase_a.
 IPR023561; Carbonic_anhydrase_a-class.
 IPR018338; Carbonic_anhydrase_a-class_CS.
 IPR018442; Carbonic_anhydrase_CA1. 
Pfam
 PF00194; Carb_anhydrase 
SMART
 SM01057; Carb_anhydrase 
PROSITE
 PS00162; ALPHA_CA_1
 PS51144; ALPHA_CA_2 
PRINTS