UniProt Accession

 MSCS_ECOLI; P0C0S1; P11666; Q2M9R8 

Genbank Protein ID

 X14436; U28377; U00096; AP009048 

Genbank Nucleotide ID

 CAA32606.1; AAA69091.1; AAC75961.1; BAE76988.1 

Protein Name

 Small-conductance mechanosensitive channel 

Protein Synonyms/Alias

  

Gene Name

 mscS 

Gene Synonyms/Alias

 yggB; b2924; JW2891 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
161	TMRTADGKIIVIPNG	acetylation	[1]
169	IIVIPNGKIIAGNII	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage; as the membrane is depolarized, less tension is required to open the channel and vice versa. The channel is characterized by short bursts of activity that last for a few seconds. 

Sequence Annotation

  

Keyword

 3D-structure; Cell inner membrane; Cell membrane; Complete proteome; Ion channel; Ion transport; Membrane; Reference proteome; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 286 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IDA:EcoCyc.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0008381; F:mechanically-gated ion channel activity; IDA:EcoCyc.
 GO:0009992; P:cellular water homeostasis; IMP:EcoCyc. 

Interpro

 IPR010920; LSM_dom.
 IPR011066; MscC_channel_C.
 IPR006685; MscS_channel.
 IPR006686; MscS_channel_CS.
 IPR011014; MscS_channel_TM-2.
 IPR008910; TM_helix. 

Pfam

 PF00924; MS_channel
 PF05552; TM_helix 

SMART

  

PROSITE

 PS01246; UPF0003 

PRINTS