CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008651
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 U3 small nucleolar RNA-associated protein 22 
Protein Synonyms/Alias
 U3 snoRNA-associated protein 22; U three protein 22 
Gene Name
 UTP22 
Gene Synonyms/Alias
 YGR090W 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
470QTPTLFDKSTKVNILacetylation[1]
1158KYLNLKYKNSLILSSmethylation[2]
1205VNLDCNVKPVDDENVubiquitination[3]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Identification of arginine- and lysine-methylation in the proteome of Saccharomyces cerevisiae and its functional implications.
 Pang CN, Gasteiger E, Wilkins MR.
 BMC Genomics. 2010 Feb 5;11:92. [PMID: 20137074]
 [3] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. 
Sequence Annotation
 MOD_RES 10 10 Phosphoserine.
 MOD_RES 58 58 Phosphoserine.
 MOD_RES 60 60 Phosphothreonine.
 MOD_RES 64 64 Phosphoserine.  
Keyword
 Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosome biogenesis; RNA-binding; rRNA processing. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1237 AA 
Protein Sequence
MATSVKRKAS ETSDQNIVKV QKKHSTQDST TDNGSKENDH SSQAINERTV PEQENDESDT 60
SPESNEVATN TAATRHNGKV TATESYDIHI ARETAELFKS NIFKLQIDEL LEQVKLKQKH 120
VLKVEKFLHK LYDILQEIPD WEEKSLAEVD SFFKNKIVSV PFVDPKPIPQ NTNYKFNYKK 180
PDISLIGSFA LKAGIYQPNG SSIDTLLTMP KELFEKKDFL NFRCLHKRSV YLAYLTHHLL 240
ILLKKDKLDS FLQLEYSYFD NDPLLPILRI SCSKPTGDSL SDYNFYKTRF SINLLIGFPY 300
KVFEPKKLLP NRNCIRIAQE SKEQSLPATP LYNFSVLSSS THENYLKYLY KTKKQTESFV 360
EATVLGRLWL QQRGFSSNMS HSGSLGGFGT FEFTILMAAL LNGGGINSNK ILLHGFSSYQ 420
LFKGVIKYLA TMDLCHDGHL QFHSNPENSS SSPASKYIDE GFQTPTLFDK STKVNILTKM 480
TVSSYQILKE YAGETLRMLN NVVQDQFSNI FLTNISRFDN LKYDLCYDVQ LPLGKYNNLE 540
TSLAATFGSM ERVKFITLEN FLAHKITNVA RYALGDRIKY IQIEMVGQKS DFPITKRKVY 600
SNTGGNHFNF DFVRVKLIVN PSECDKLVTK GPAHSETMST EAAVFKNFWG IKSSLRRFKD 660
GSITHCCVWS TSSSEPIISS IVNFALQKHV SKKAQISNET IKKFHNFLPL PNLPSSAKTS 720
VLNLSSFFNL KKSFDDLYKI IFQMKLPLSV KSILPVGSAF RYTSLCQPVP FAYSDPDFFQ 780
DVILEFETSP KWPDEITSLE KAKTAFLLKI QEELSANSST YRSFFSRDES IPYNLEIVTL 840
NILTPEGYGF KFRVLTERDE ILYLRAIANA RNELKPELEA TFLKFTAKYL ASVRHTRTLE 900
NISHSYQFYS PVVRLFKRWL DTHLLLGHIT DELAELIAIK PFVDPAPYFI PGSLENGFLK 960
VLKFISQWNW KDDPLILDLV KPEDDIRDTF ETSIGAGSEL DSKTMKKLSE RLTLAQYKGI 1020
QMNFTNLRNS DPNGTHLQFF VASKNDPSGI LYSSGIPLPI ATRLTALAKV AVNLLQTHGL 1080
NQQTINLLFT PGLKDYDFVV DLRTPIGLKS SCGILSATEF KNITNDQAPS NFPENLNDLS 1140
EKMDPTYQLV KYLNLKYKNS LILSSRKYIG VNGGEKGDKN VITGLIKPLF KGAHKFRVNL 1200
DCNVKPVDDE NVILNKEAIF HEIAAFGNDM VINFETD 1237 
Gene Ontology
 GO:0032545; C:CURI complex; IDA:SGD.
 GO:0032040; C:small-subunit processome; IDA:SGD.
 GO:0034456; C:UTP-C complex; IDA:SGD.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IC:SGD.
 GO:0006409; P:tRNA export from nucleus; IMP:SGD. 
Interpro
 IPR005554; Nrap. 
Pfam
 PF03813; Nrap 
SMART
  
PROSITE
  
PRINTS