UniProt Accession

 SPT4H_DROME; Q9TVQ5; Q9V6E5 

Genbank Protein ID

 AF108353; AF109133; AE013599; AY075424 

Genbank Nucleotide ID

 AAF14223.1; AAF14224.1; AAF58482.2; AAL68240.1 

Protein Name

 Transcription elongation factor SPT4 

Protein Synonyms/Alias

 DRB sensitivity-inducing factor small subunit; DSIF small subunit; dSpt4 

Gene Name

 spt4 

Gene Synonyms/Alias

 CG12372 

Created Date

 July 27, 2013 

Organism

 Drosophila melanogaster (Fruit fly) 

NCBI Taxa ID

 7227 

Lysine Modification

Position	Peptide	Type	References
8	MAFDAIPKDLRGLRA	acetylation	[1]

Reference

 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 

Functional Description

 Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. DSIF enhances transcriptional pausing at sites proximal to the promoter, which may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF may also promote transcriptional elongation within coding regions. DSIF is required for the transcriptional induction of heat shock response genes and regulation of genes which control anterior-posterior patterning during embryonic development (By similarity). 

Sequence Annotation

 ZN_FING 16 36 C4-type (Potential).
 REGION 1 40 Interaction with Spt5 (By similarity).  

Keyword

 Activator; Complete proteome; Metal-binding; Nucleus; Reference proteome; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 116 AA 

Protein Sequence

Gene Ontology

 GO:0005705; C:polytene chromosome interband; IDA:UniProtKB.
 GO:0005703; C:polytene chromosome puff; IDA:UniProtKB.
 GO:0008023; C:transcription elongation factor complex; IDA:FlyBase.
 GO:0046982; F:protein heterodimerization activity; ISS:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0032785; P:negative regulation of DNA-dependent transcription, elongation; IDA:UniProtKB.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
 GO:0032786; P:positive regulation of DNA-dependent transcription, elongation; ISS:UniProtKB.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
 GO:0006368; P:transcription elongation from RNA polymerase II promoter; IDA:UniProtKB. 

Interpro

 IPR009287; Spt4.
 IPR016046; Spt4-like.
 IPR022800; Spt4/RpoE2_Znf. 

Pfam

 PF06093; Spt4 

SMART

  

PROSITE

  

PRINTS