UniProt Accession

 MRP_MOUSE; P28667; Q3TEZ4; Q91W07 

Genbank Protein ID

 X61399; S65597; AK079390; AK083913; AK152990; AK169355; BC006757 

Genbank Nucleotide ID

 CAA43671.1; AAP13962.1; BAC37630.1; BAC39058.1; BAE31636.1; BAE41104.1; AAH06757.1 

Protein Name

 MARCKS-related protein 

Protein Synonyms/Alias

 Brain protein F52; MARCKS-like protein 1; Macrophage myristoylated alanine-rich C kinase substrate; Mac-MARCKS; MacMARCKS 

Gene Name

 Marcksl1 

Gene Synonyms/Alias

 Mlp; Mrp 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
25	AAGASPAKANGQENG	ubiquitination	[1]
106	KLSGLSFKRNRKEGG	acetylation	[2]
157	ESQEPQAKGAEASAA	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May also affect cancer cell migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems. 

Sequence Annotation

 REGION 87 110 Effector domain involved in lipid-
 REGION 87 100 Calmodulin-binding (PSD).
 MOD_RES 22 22 Phosphoserine.
 MOD_RES 36 36 Phosphoserine.
 MOD_RES 48 48 Phosphoserine.
 MOD_RES 71 71 Phosphoserine.
 MOD_RES 85 85 Phosphothreonine.
 MOD_RES 93 93 Phosphoserine; by PKC (By similarity).
 MOD_RES 101 101 Phosphoserine; by PKC (By similarity).
 MOD_RES 104 104 Phosphoserine; by PKC.
 MOD_RES 120 120 Phosphoserine; by MAPK8.
 MOD_RES 135 135 Phosphoserine.
 MOD_RES 148 148 Phosphothreonine; by MAPK8.
 MOD_RES 151 151 Phosphoserine (By similarity).
 MOD_RES 162 162 Phosphoserine.
 MOD_RES 165 165 Phosphoserine.
 MOD_RES 170 170 Phosphothreonine.
 MOD_RES 183 183 Phosphothreonine; by MAPK8.
 MOD_RES 185 185 Phosphoserine.
 MOD_RES 192 192 Phosphothreonine.
 LIPID 2 2 N-myristoyl glycine.  

Keyword

 Actin-binding; Calmodulin-binding; Cell membrane; Complete proteome; Cytoplasm; Lipoprotein; Membrane; Myristate; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 200 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0008284; P:positive regulation of cell proliferation; IDA:MGI. 

Interpro

 IPR002101; MARCKS. 

Pfam

 PF02063; MARCKS 

SMART

  

PROSITE

 PS00826; MARCKS_1
 PS00827; MARCKS_2 

PRINTS

 PR00963; MARCKS.