CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031486
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Leucine-rich repeat and calponin homology domain-containing protein 3 
Protein Synonyms/Alias
 cDNA FLJ61518, highly similar to Homo sapiens leucine-rich repeats and calponin homology (CH) domain containing 3 (LRCH3), mRNA 
Gene Name
 LRCH3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
153HLCNLPLKVLIASNNubiquitination[1]
161VLIASNNKLVSLPEEubiquitination[1]
229RLDFSCNKITTIPVCubiquitination[2]
344LRVAEITKEQRLRREubiquitination[1]
403VAIREFQKTEDMRRYubiquitination[1]
466ALQYEEEKIRTKQIQubiquitination[1, 3]
679NFLEACRKIGVPQEQubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 725 AA 
Protein Sequence
MAAAGLVAVA AAAEYSGTVA SGGNLPGVHC GPSSGAGPGF GPGSWSRSLD RALEEAAVTG 60
VLSLSGRKLR EFPRGAANHD LTDTTRADLS RNRLSEIPIE ACHFVSLENL NLYQNCIRYI 120
PEAILNLQAL TFLNISRNQL STLPVHLCNL PLKVLIASNN KLVSLPEEIG HLRHLMELDV 180
SCNEIQTIPS QIGNLEALRD LNVRRNHLVH LPEELAELPL IRLDFSCNKI TTIPVCYRNL 240
RHLQTITLDN NPLQSPPAQI CIKGKVHIFK YLNIQACKIA PDLPDYDRRP LGFGSCHEEL 300
YSSRPYGALD SGFNSVDSGD KRWSGNEPTD EFSDLPLRVA EITKEQRLRR ESQYQENRGS 360
LVVTNGGVEH DLDQIDYIDS CTAEEEEAEG SPVKPVAIRE FQKTEDMRRY LHQNRVPAEP 420
SSLLSLSASH NQLSHTDLEL HQRREQLVER TRREAQLAAL QYEEEKIRTK QIQRDAVLDF 480
VKQKASQSPQ KQHPLLDGVD GECPFPSRRS QHTDDSALCM SDDRPNALLS SPATETVHHS 540
PAYSFPAAIQ RNQPQRPESF LFRAGVRAET NKGHASPLPP SAAPTTDSTD SITGQNSRQR 600
EEELELIDQL RKHIEYRLKV SLPCDLGAAL TDGVVLCHLA NHVRPRSVPS IHVPSPAVPK 660
LTMAKCRRNV ENFLEACRKI GVPQEQLCLP LHILEEKGLS QVAVTVQALL ELAPPKQQQH 720
QLSAV 725 
Gene Ontology
  
Interpro
 IPR001715; CH-domain.
 IPR001611; Leu-rich_rpt. 
Pfam
 PF00307; CH
 PF00560; LRR_1 
SMART
 SM00033; CH 
PROSITE
 PS50021; CH 
PRINTS